Amoxicillin Injection for Veterinary Use | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical antibiotic in veterinary medicine, designed to combat bacterial infections in livestock such as cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product exemplifies the intersection of pharmaceutical innovation and animal health care. This article delves into its pharmacokinetic properties, clinical applications, safety profile, and the company's commitment to quality. For detailed specifications, visit the official product page: Amoxicillin Injection Product Page.

Pharmacokinetic Properties

Amoxicillin belongs to the amino-penicillin family, structurally related to ampicillin. It functions as a bactericidal agent, effective against both Gram-positive and Gram-negative bacteria. Its mechanism involves inhibiting bacterial cell wall synthesis and repair. However, it is susceptible to beta-lactamases, enzymes produced by some bacteria that can degrade penicillin antibiotics.

Key Pharmacokinetic Data:

• Cattle: Maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours post-injection.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with a low plasma protein binding rate (17%). It reaches similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma.
• Metabolism: The liver metabolizes amoxicillin via hydrolysis of the beta-lactam ring, forming inactive penicilloic acid (20% of the drug).
• Excretion: The majority is excreted via the kidneys, with secondary routes including the biliary system and milk.

Read More About Amoxicillin Injection Uses

Clinical Applications

Amoxicillin Injection is indicated for treating infections caused by susceptible bacteria in cattle and pigs. It is particularly effective against Mannheimia haemolytica and Pasteurella multocida, which are common pathogens in respiratory diseases. Its broad-spectrum activity makes it a versatile choice for veterinary practitioners.

Target Species: Cattle and pigs.

Indications: Respiratory infections, skin and soft tissue infections, and other bacterial conditions sensitive to amoxicillin.

Safety Profile and Adverse Reactions

While amoxicillin is generally well-tolerated, it carries risks of hypersensitivity reactions, including allergic responses. It should not be administered to animals with known allergies to beta-lactam antibiotics. Local reactions at the injection site, such as swelling or redness, may occur but are typically transient.

Important Warnings:

• Shake well before use to ensure uniform distribution of the active ingredient.
• Milk for human consumption must be withheld during treatment. For cattle, milk can be safely consumed only after 96 hours post-treatment.

Withdrawal Periods

Withdrawal periods are critical to ensure food safety and compliance with regulatory standards:

• Cattle and Pigs: 28 days.
• Milk: 4 hours.

These periods allow the drug to be metabolized and eliminated from the animal's system, minimizing residues in food products.

Storage and Packaging

Proper storage is essential to maintain the efficacy of Amoxicillin Injection:

• Storage Conditions: Keep sealed, protect from light, and store out of reach of children.
• Packaging: 100ml/bottle.
• Shelf Life: 3 years from the date of manufacture.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Indication	Treatment of bacterial infections in cattle and pigs
Administration Route	Intramuscular
Pharmacokinetic Data	Cmax in cattle: 3.45 µg/ml (2.45h); Cmax in pigs: 3.54 µg/ml (2h)
Withdrawal Period	28 days (meat), 4 hours (milk)
Storage	Sealed, protected from light, 3 years shelf life

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to advancing animal health through innovative solutions. With a focus on quality and compliance, the company adheres to rigorous standards to ensure the safety and efficacy of its products. Their commitment to research and development has positioned them as a trusted partner in the veterinary industry.

For more information about the company, visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Authoritative References and Compliance

The development and use of Amoxicillin Injection align with the standards set by authoritative bodies such as the National Institute of Standards and Technology (NIST). NIST plays a pivotal role in establishing measurement standards that underpin pharmaceutical research and quality control. While specific NIST references for this product are not available, the principles of precision and reliability in drug formulation are consistent with NIST's mission to advance technological innovation. For further insights into NIST's work, visit their official website: NIST Official Website.

Reference: National Institute of Standards and Technology (NIST). (2025). Standards for Pharmaceutical Research and Development. Retrieved from https://www.nist.gov.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and adherence to safety standards make it a preferred choice for veterinarians. Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to uphold its reputation for quality, ensuring that this product meets the highest industry benchmarks. For detailed information, consult the official product page: Amoxicillin Injection Product Page.