Amoxicillin Injection for Veterinary Use | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin injection is a critical tool in veterinary medicine, offering broad-spectrum antibacterial activity against a wide range of pathogens. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is designed to treat bacterial infections in livestock, including cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and technical specifications, supported by authoritative references and industry insights.

Product Overview

Amoxicillin injection is a semisynthetic penicillin antibiotic derived from ampicillin. It belongs to the amino-penicillin family and is effective against both Gram-positive and Gram-negative bacteria. The drug works by inhibiting bacterial cell wall synthesis, making it a bactericidal agent. Its mechanism of action involves targeting the peptidoglycan layer of bacterial cells, which is essential for structural integrity and replication.

Key features of amoxicillin injection include:

• Broad-spectrum activity against respiratory pathogens in cattle and pigs.
• Time-dependent efficacy, requiring consistent plasma concentrations for optimal results.
• Low plasma protein binding (17%), facilitating rapid distribution to tissues.
• Short withdrawal periods for milk and meat, ensuring compliance with food safety standards.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin injection is essential for optimizing its therapeutic use. Here’s a detailed breakdown:

Peak Plasma Concentration (Cmax)

In cattle, the peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration. In pigs, the Cmax reaches 3.54 µg/ml within 2 hours. These values indicate the drug’s rapid absorption and distribution in the bloodstream.

Distribution and Tissue Penetration

Amoxicillin is primarily distributed to the extracellular compartment. Its low plasma protein binding (17%) allows it to diffuse into tissues such as the lungs, pleura, and bronchial tissues, where it achieves concentrations comparable to plasma levels. The drug also penetrates pleural and synovial fluids, as well as lymphatic tissues, making it effective against localized infections.

Metabolism and Excretion

After administration, amoxicillin undergoes hepatic metabolism, where the β-lactam ring is hydrolyzed into inactive penicilloic acid (20% of the dose). The majority of the drug is excreted unchanged via the kidneys, with a secondary route through the biliary system and milk. This excretion profile ensures prolonged therapeutic effects while minimizing systemic toxicity.

Adverse Reactions and Safety Profile

While amoxicillin injection is generally well-tolerated, it is not without risks. As with all β-lactam antibiotics, hypersensitivity reactions (allergies) can occur. Animals with known allergies to penicillins should not receive this medication. Localized transient reactions at the injection site may also be observed, though they are typically mild and resolve without intervention.

Important Warnings:

• Shake the vial well before use to ensure uniform suspension.
• Do not use milk from treated animals for human consumption during treatment. For cattle, milk may be used only after 96 hours post-treatment.

Withdrawal Periods and Storage

Adhering to withdrawal periods is critical for ensuring food safety and regulatory compliance:

• Cattle and pigs: 28 days
• Milk: 4 hours

Storage instructions emphasize stability and safety:

• Keep sealed and protected from light
• Store out of reach of children
• Packaging: 100ml/bottle
• Shelf life: 3 years

Applications in Veterinary Medicine

Amoxicillin injection is widely used to treat bacterial infections in livestock, particularly those caused by respiratory pathogens. Key applications include:

• Cattle: Mannheimia haemolytica and Pasteurella multocida infections
• Pigs: Pasteurella multocida infections

Its efficacy in these contexts is supported by clinical studies and real-world usage, making it a staple in veterinary pharmacology. For more information on its specific uses, visit the product page.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and related products. With a focus on innovation and compliance, the company ensures its products meet international standards for safety and efficacy. Their commitment to research and development has positioned them as a trusted name in the veterinary healthcare industry.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Formulation	Injectable solution
Administration Route	Intramuscular
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage Conditions	Sealed, protected from light, out of reach of children
Shelf Life	3 years

Conclusion

Amoxicillin injection is a vital medication in veterinary practice, offering effective treatment for bacterial infections in livestock. Its pharmacokinetic profile, safety considerations, and regulatory compliance make it a reliable choice for veterinarians and farmers. By adhering to proper administration protocols and withdrawal periods, users can maximize its benefits while ensuring food safety. For further details on the product, visit the company website or consult the product page.

References

1. National Institute of Standards and Technology (NIST). "What We Do." https://www.nist.gov. NIST, 2025. Accessed 2025-09-15.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. "Amoxicillin Injection." https://www.skyvetpharm.com/amoxicillin-injection.html. 2025.