Amoxicillin Injection for Veterinary Use | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical pharmaceutical product designed for the treatment of bacterial infections in veterinary medicine. As a broad-spectrum antibiotic, it belongs to the amino-penicillin family and is known for its efficacy against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, applications, advantages, technical specifications, and the company behind its production.

Pharmacokinetic Properties

Amoxicillin is a bactericidal antibiotic that inhibits the synthesis and repair of bacterial cell walls by targeting the mucopeptide layer. Its structural similarity to ampicillin allows it to effectively combat a wide range of pathogens. However, it is susceptible to bacterial beta-lactamases, which can reduce its efficacy in certain cases. The drug is classified as a time-dependent antibiotic, meaning its effectiveness is closely related to the duration of exposure to the pathogen rather than peak concentration.

Pharmacokinetic Data:

• Cattle: Maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours post-administration.
• Distribution: Amoxicillin primarily distributes to the extracellular compartment due to its low plasma protein binding (17%). It accumulates in pulmonary, pleural, and bronchial tissues, as well as in pleural, synovial, and lymphatic fluids.
• Metabolism: The liver metabolizes amoxicillin via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the drug).
• Excretion: The kidneys excrete the majority of the drug in its active form, with secondary excretion via the biliary route and milk.

Read More About amoxicillin injection uses

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice to treat respiratory infections in livestock. It is particularly effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease. Similarly, it targets Pasteurella multocida in swine, making it a versatile choice for managing respiratory ailments in cattle and pigs.

Key Indications:

• Treatment of bacterial infections caused by Gram-positive and Gram-negative organisms.
• Management of respiratory diseases in cattle and pigs.
• Support for post-surgical infections and wound care in veterinary settings.

Advantages of Amoxicillin Injection

Several factors make Amoxicillin Injection a preferred choice in veterinary medicine:

• Fast Onset: Rapid absorption and distribution ensure quick therapeutic effects.
• Wide Spectrum: Effective against a broad range of pathogens, reducing the need for multiple medications.
• Safe Profile: Generally well-tolerated, with minimal side effects when used as directed.
• Convenient Administration: Available in a 100ml bottle, allowing for easy dosing in large animals.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable solution
Administration Route	Intramuscular
Withdrawal Period	Cattle and Pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Important Safety Information

Adverse Reactions: As with all penicillins, hypersensitivity (allergic) reactions may occur. It should not be used in animals with a known allergy to beta-lactams. Local reactions at the injection site, such as swelling or redness, may occur but are typically transient.

Special Warnings:

• Shake the solution well before use to ensure proper mixing.
• Milk for human consumption must not be used during treatment. For cattle, milk can be consumed only after 96 hours post-treatment.

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer specializing in veterinary pharmaceuticals. With a focus on quality and innovation, the company produces a wide range of products to address the needs of livestock health. Their commitment to research and development ensures that their formulations meet the highest standards of efficacy and safety.

For more information about their products and services, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Conclusion

Amoxicillin Injection is an essential tool in veterinary medicine, offering a reliable solution for treating bacterial infections in cattle and pigs. Its favorable pharmacokinetic profile, broad-spectrum activity, and ease of administration make it a preferred choice for veterinarians. When used responsibly, it contributes to the health and productivity of livestock while adhering to strict safety guidelines.

References

1. National Institute of Standards and Technology (NIST). NIST plays a critical role in developing standards and measurements that ensure the quality and reliability of pharmaceutical products. Their work supports the accuracy of medical devices and drug formulations, contributing to public health and safety.

2. Amoxicillin Injection Product Page. Detailed specifications and usage guidelines for veterinary applications.