Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a vital pharmaceutical product in the veterinary industry, designed to combat bacterial infections in livestock such as cattle and pigs. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is a cornerstone in treating respiratory diseases caused by both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and the company's commitment to quality.

Read More About amoxicillin injection uses

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic that belongs to the amino-penicillin family. It is specifically formulated for veterinary use to address bacterial infections in cattle and pigs. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly. Its active ingredient, amoxicillin, is present at a concentration of 150mg per ml, making it a potent solution for treating infections caused by a wide range of bacteria.

Veterinary amoxicillin injection is a critical tool in modern animal husbandry, ensuring the health and productivity of livestock. The drug's broad-spectrum activity against both Gram-positive and Gram-negative bacteria, such as Mannheimia haemolytica and Pasteurella multocida, makes it indispensable in managing respiratory diseases in cattle and pigs.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin is essential for optimizing its therapeutic efficacy. Here's a detailed breakdown:

• Bioavailability: After intramuscular administration, amoxicillin reaches peak plasma concentrations (Cmax) of 3.45 µg/ml in cattle within 2.45 hours and 3.54 µg/ml in pigs within 2 hours.
• Distribution: The drug is primarily distributed in the extracellular compartment, with a low plasma protein binding rate (17%). It effectively diffuses into tissues such as the lungs, pleura, and synovial fluid, ensuring adequate concentrations at infection sites.
• Metabolism: Amoxicillin is metabolized in the liver through hydrolysis of its β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: The majority of the drug is excreted unchanged via the kidneys, with secondary excretion through the biliary route and milk.

These pharmacokinetic characteristics highlight the drug's ability to maintain therapeutic levels in the body, ensuring effective bacterial inhibition.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice for treating bacterial infections in livestock. Its primary applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease (BRD) and porcine respiratory disease (PRD).
• Systemic Infections: Treats infections caused by Gram-positive and Gram-negative bacteria, including those affecting the skin, urinary tract, and soft tissues.
• Preventive Use: Often administered prophylactically to prevent post-surgical infections in livestock.

The drug's time-dependent mechanism of action ensures that sustained plasma concentrations are critical for optimal bacterial killing, making it a preferred choice for chronic or recurrent infections.

Safety and Adverse Reactions

While amoxicillin injection uses are extensive, it is essential to consider its safety profile:

• Allergic Reactions: As with all penicillins, hypersensitivity reactions (e.g., anaphylaxis) may occur in animals with a known allergy to β-lactam antibiotics.
• Local Reactions: Transient injection site reactions, such as swelling or irritation, may occur but are generally mild.
• Milk Withdrawal Period: Milk from treated animals must not be used for human consumption during treatment. For cattle, the withdrawal period is 96 hours post-treatment.
• Withdrawal Period: A 28-day withdrawal period is required for meat from cattle and pigs to ensure residues are below acceptable limits.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to strict quality control measures to minimize adverse effects and ensure compliance with regulatory standards.

Storage and Handling

Proper storage is crucial for maintaining the efficacy of amoxicillin injection:

• Storage Conditions: Keep the product sealed and protected from light. Store in a cool, dry place away from direct sunlight.
• Child Safety: Keep the medication out of reach of children to prevent accidental ingestion.
• Shelf Life: The product has a shelf life of 3 years when stored under recommended conditions.

Before use, shake the bottle well to ensure homogeneity of the solution. Always follow the manufacturer's instructions for administration to avoid complications.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria.
Withdrawal Period (Meat)	28 days for cattle and pigs
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light, and stored at room temperature
Shelf Life	3 years
Packaging	100ml/bottle

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality solutions for livestock health. With a strong emphasis on research and development, the company ensures that its products meet international standards for safety and efficacy.

As a trusted name in the veterinary industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to rigorous quality control protocols, including compliance with Good Manufacturing Practices (GMP). The company's commitment to innovation and customer satisfaction has established it as a key player in the global veterinary market.

Conclusion

Amoxicillin Injection is an essential tool in veterinary medicine, offering a reliable solution for treating bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and established safety record make it a preferred choice for veterinarians and farmers alike. Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to lead in providing high-quality pharmaceutical products that contribute to the health and productivity of animals.

References

As per the National Institute of Standards and Technology (NIST), authoritative standards and measurements are critical in ensuring the reliability of pharmaceutical products. While NIST does not directly regulate veterinary medications, its role in developing measurement standards supports the broader scientific community in maintaining product quality and safety.

Reference: https://www.nist.gov/