Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Broad-Spectrum Antibacterial Treatment&Veterinary Use

Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a critical veterinary medication designed to combat bacterial infections in livestock. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, applications, and the company's commitment to quality. For detailed product information, visit the Amoxicillin Injection product page.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic derived from ampicillin. It belongs to the amino-penicillin family and is effective against a wide range of Gram-positive and Gram-negative bacteria. This medication is specifically formulated for veterinary use, targeting respiratory infections in cattle and pigs. Its active ingredient, amoxicillin, works by inhibiting bacterial cell wall synthesis, making it a bactericidal agent.

Pharmacokinetic Properties

Amoxicillin Injection exhibits favorable pharmacokinetic characteristics, ensuring rapid and effective therapeutic action. Key properties include:

• Peak Concentration (Cmax): In cattle, Cmax reaches 3.45 µg/ml 2.45 hours post-intramuscular administration. In pigs, Cmax is 3.54 µg/ml 2 hours after administration.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with low plasma protein binding (17%). It achieves similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the dose).
• Excretion: Amoxicillin is predominantly excreted via the kidneys in its active form, with secondary elimination through the biliary route and milk.

Advantages of Amoxicillin Injection

The unique properties of amoxicillin injection make it a preferred choice for veterinary professionals. Key advantages include:

• Broad-Spectrum Activity: Effective against both Gram-positive and Gram-negative bacteria, including Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Time-Dependent Efficacy: Its mechanism of action is optimized with sustained drug concentrations, ensuring prolonged bacterial suppression.
• Minimal Protein Binding: Low plasma protein binding allows for rapid distribution to target tissues, enhancing therapeutic outcomes.
• Convenient Administration: Available in a 100ml bottle, it offers flexibility for intramuscular use in livestock.

Technical Specifications

Parameter	Details
Composition	150mg amoxicillin per ml
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage	Seal, protect from light, and keep out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle

Applications in Veterinary Medicine

Amoxicillin injection is widely used in veterinary practice for treating bacterial infections in livestock. Its primary applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine and porcine respiratory diseases.
• Systemic Infections: Targets bacteria affecting multiple organ systems, including those causing septicemia and abscesses.
• Post-Operative Prophylaxis: Prevents bacterial infections following surgical procedures in livestock.

Adverse Reactions and Precautions

While amoxicillin injection is generally well-tolerated, certain precautions must be observed:

• Hypersensitivity: May cause allergic reactions in animals with a known allergy to beta-lactam antibiotics.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Milk Withdrawal: Milk from treated cattle should not be used for human consumption during treatment. It can be safely used after 96 hours post-last dose.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Based in Shijiazhuang, China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals. The company adheres to stringent quality control standards to ensure the efficacy and safety of its products. Their commitment to innovation and customer satisfaction has established them as a trusted name in the veterinary industry.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in veterinary medicine, offering broad-spectrum antibacterial activity with favorable pharmacokinetic properties. Its ease of administration, minimal adverse effects, and proven efficacy make it a preferred choice for treating bacterial infections in cattle and pigs. For more information, explore the Amoxicillin Injection product page.

References

For authoritative information on pharmaceutical standards, refer to the National Institute of Standards and Technology (NIST). NIST provides critical guidelines for drug development and quality assurance in the healthcare industry.