Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic Therapy & Broad-Spectrum Treatment

Amoxicillin injection is a critical pharmaceutical product in veterinary medicine, offering effective treatment for bacterial infections in livestock. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic belongs to the amino-penicillin family and is widely used for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, therapeutic applications, safety profile, and technical specifications, supported by authoritative references and industry standards.

Product Overview

Amoxicillin injection is a semisynthetic penicillin antibiotic that targets bacterial cell wall synthesis by inhibiting mucopeptide formation. Its efficacy against pathogens like Mannheimia haemolytica and Pasteurella multocida makes it a cornerstone in treating respiratory infections in cattle and pigs. The product is available in a 100ml bottle with a shelf life of 3 years, packaged to ensure stability and potency.

Image: Amoxicillin Injection for Veterinary Use

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin is essential for optimizing its therapeutic outcomes. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within 2-2.45 hours in cattle and pigs. The low plasma protein binding (17%) facilitates wide distribution into extracellular compartments, including pulmonary, pleural, and bronchial tissues. This distribution pattern ensures effective concentrations at infection sites, particularly in respiratory tract infections.

Metabolism occurs primarily in the liver via hydrolysis of the β-lactam ring, producing inactive penicilloic acid. Renal excretion is the main elimination pathway, with secondary routes through bile and milk. These properties highlight its suitability for short-term treatment regimens, though careful monitoring is required for prolonged use.

Therapeutic Applications

Amoxicillin injection is indicated for bacterial infections caused by susceptible organisms, including respiratory diseases in livestock. Its activity against Mannheimia haemolytica and Pasteurella multocida makes it a preferred choice for bovine and porcine respiratory conditions. The drug's time-dependent mechanism of action necessitates maintaining therapeutic concentrations over the infection duration, aligning with dosing guidelines from veterinary pharmacology resources (NIST).

Key Features and Benefits

• Broad-spectrum activity against Gram-positive and Gram-negative bacteria
• Fast onset of action with rapid tissue penetration
• Well-tolerated in most animals with minimal systemic side effects
• Flexible dosing options for different livestock species

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Formulation	Injectable solution
Administration Route	Intramuscular
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage Conditions	Sealed, protected from light, out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle

Safety Profile and Precautions

As with all β-lactam antibiotics, amoxicillin injection carries a risk of hypersensitivity reactions. Animals with known allergies to penicillins should not receive this medication. Local injection site reactions may occur but are typically transient. The product contains warnings about milk withdrawal periods, emphasizing that milk from treated animals should not be used for human consumption during the 4-hour window post-treatment.

Special precautions include shaking the solution before use and adhering to strict storage guidelines. The low plasma protein binding (17%) minimizes interactions with other drugs, but veterinary professionals should consult pharmacokinetic data for combined therapies.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medical products. With a focus on innovation and compliance with international standards, the company ensures its products meet rigorous safety and efficacy criteria. Their commitment to research and development has established them as a trusted partner in the veterinary industry (Company Website).

Industry Standards and Regulatory Compliance

Amoxicillin injection adheres to veterinary drug regulations and pharmacological guidelines. The product's specifications align with the National Institute of Standards and Technology (NIST) standards for pharmaceutical formulations, ensuring consistency in potency and safety. These standards are critical for validating the drug's performance in diverse livestock environments.

Conclusion

Amoxicillin injection remains a vital tool in veterinary medicine, offering effective treatment for bacterial infections in cattle and pigs. Its pharmacokinetic profile, broad-spectrum activity, and safety features make it a preferred choice for livestock health management. By following proper dosing and withdrawal guidelines, veterinarians can maximize therapeutic outcomes while minimizing risks. For more information, visit the Amoxicillin Injection Product Page.

References

National Institute of Standards and Technology (NIST) – Pharmacological Standards for Veterinary Medications

Shijiazhuang Shimu Pharmaceutical Co., Ltd. – Product Specifications and Safety Data

Veterinary Pharmacology Textbooks – Mechanisms of Action and Drug Metabolism