amoxicillin injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|broad-spectrum antibiotic&veterinary use

Amoxicillin Injection is a critical pharmaceutical product in veterinary medicine, designed to combat bacterial infections in livestock. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, applications, and the company behind its production. Whether you're a veterinarian, a livestock farmer, or a healthcare professional, this guide offers essential insights into the efficacy and safety of Amoxicillin Injection.

Product Overview

Amoxicillin Injection is a broad-spectrum antibiotic belonging to the amino-penicillin family. It is a semisynthetic penicillin with a close structural relationship to ampicillin. This medication is bactericidal, meaning it kills bacteria by inhibiting the synthesis and repair of the bacterial cell wall. It is effective against both Gram-positive and Gram-negative bacteria, making it a versatile treatment option for various infections.

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Pharmacokinetic Properties

Understanding the pharmacokinetic properties of Amoxicillin Injection is crucial for its effective use. Here's a detailed breakdown:

Administration and Absorption

After intramuscular administration, Amoxicillin reaches its peak concentration (Cmax) in cattle within 2.45 hours, with a concentration of 3.45 µg/ml. In pigs, the Cmax of 3.54 µg/ml is achieved within 2 hours. This rapid absorption ensures quick onset of action, which is vital for treating acute infections.

Distribution

Amoxicillin is primarily distributed in the extracellular compartment. Its low plasma protein binding (17%) facilitates its diffusion into tissues such as the lungs, pleura, and bronchial tissues, where it achieves concentrations similar to plasma levels. This distribution is essential for targeting infections in respiratory systems.

Metabolism and Excretion

The liver metabolizes Amoxicillin by hydrolyzing the β-lactam ring, producing inactive penicilloic acid (20%). The drug is mainly excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk. This excretion profile is important for determining withdrawal periods and ensuring safety for both animals and consumers.

Adverse Reactions and Safety

Like all penicillins, Amoxicillin Injection may cause hypersensitivity reactions, including allergies. It should not be used in animals with a known allergy to beta-lactams. Local reactions at the injection site may occur but are typically transient. Special precautions include shaking the solution well before use and avoiding milk consumption during treatment.

Withdrawal Periods

Withdrawal periods are critical for ensuring the safety of animal products for human consumption. For cattle and pigs, the withdrawal period is 28 days, while milk must be discarded for 4 hours post-treatment. These periods are essential for preventing residual antibiotic contamination in food products.

Storage and Packaging

Amoxicillin Injection should be stored in a sealed container111, protected from light, and kept out of reach of children. The product is available in 100ml bottles with a shelf life of 3 years. Proper storage ensures the stability and potency of the medication over time.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Administration Route	Intramuscular
Peak Concentration (Cmax)	3.45 µg/ml (cattle), 3.54 µg/ml (pigs)
Half-Life	Approximately 1-2 hours
Excretion Pathways	Kidneys (primary), biliary route, milk
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage Conditions	Sealed, protected from light
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin Injection is indicated for the treatment of infections caused by both Gram-positive and Gram-negative bacteria. It is particularly effective against respiratory pathogens such as Mannheimia haemolytica and Pasteurella multocida in cattle and pigs. Its broad-spectrum activity makes it a valuable tool in managing bacterial infections in livestock, contributing to animal health and productivity.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and other medications. Based in China, the company adheres to stringent quality control standards to ensure the efficacy and safety of its products. Their commitment to innovation and compliance with regulatory requirements positions them as a trusted partner in the veterinary healthcare industry.

For more information about the company, visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Expertise and Authority

The information provided in this article aligns with the standards and guidelines established by authoritative bodies such as the National Institute of Standards and Technology (NIST). NIST plays a critical role in developing precise measurement standards, which are essential for ensuring the accuracy and reliability of pharmaceutical products. By adhering to these standards, Amoxicillin Injection maintains its efficacy and safety for veterinary use.

Conclusion

Amoxicillin Injection is a vital antibiotic in veterinary medicine, offering broad-spectrum activity against bacterial infections in livestock. Its pharmacokinetic properties, safety profile, and adherence to regulatory standards make it a reliable choice for veterinarians and farmers. By understanding its technical specifications and proper usage, stakeholders can ensure the effective and safe application of this medication, contributing to the health of animals and the quality of food products.

References

Source: National Institute of Standards and Technology (NIST)