Amoxicillin Injection-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Broad-Spectrum Antibiotic&Veterinary Use

Introduction

Amoxicillin Injection is a critical tool in veterinary medicine, offering a broad-spectrum antibiotic solution for treating bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司), this product is designed to combat a wide range of pathogens, ensuring the health and productivity of animals. This article provides an in-depth analysis of its pharmacokinetic properties, applications, advantages, and technical specifications, while adhering to the (Experience, Expertise, Authoritativeness, Trustworthiness) principles.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin derived from ampicillin, known for its efficacy against both Gram-positive and Gram-negative bacteria. The product is formulated to be administered via intramuscular injection, ensuring rapid systemic absorption and targeted treatment of infections. Its primary use in veterinary settings includes addressing respiratory diseases in cattle and pigs, such as those caused by Mannheimia haemolytica and Pasteurella multocida.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a reputable pharmaceutical manufacturer, Shijiazhuang Shimu Pharmaceutical Co., Ltd. specializes in developing veterinary medications that meet international standards. With a commitment to quality and innovation, the company ensures that its products, including Amoxicillin Injection, are rigorously tested for safety and efficacy. For more information about the company's mission and product range, visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic use. Below are key parameters:

1. Absorption and Distribution

After intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) within 2–2.45 hours in cattle and pigs. The drug exhibits low plasma protein binding (17%), facilitating its distribution into extracellular compartments. It accumulates in tissues such as the lungs, pleura, bronchial tissues, and synovial fluid, achieving concentrations comparable to plasma levels.

2. Metabolism and Excretion

Amoxicillin is primarily metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%). The majority of the drug is excreted unchanged via the kidneys, with secondary elimination through the biliary route and milk. This metabolic profile ensures prolonged therapeutic effects while minimizing systemic toxicity.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used to treat bacterial infections in livestock, particularly in the following scenarios:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Systemic Infections: Targets Gram-positive and Gram-negative bacteria causing sepsis, wound infections, and urinary tract infections.
• Preventive Use: Administered in high-risk environments to reduce the spread of bacterial pathogens.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several benefits that make it a preferred choice in veterinary practice:

• Broad-Spectrum Activity: Effective against a wide range of bacterial pathogens, reducing the need for multiple antibiotics.
• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects.
• Cost-Effective: Provides high efficacy at a competitive price, making it accessible for large-scale livestock management.
• Minimal Side Effects: Generally well-tolerated, with adverse reactions occurring infrequently.

Key Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150 mg/ml)
Administration Route	Intramuscular Injection
Peak Plasma Concentration (Cmax)	Cattle: 3.45 µg/ml (2.45 hours post-administration) Pigs: 3.54 µg/ml (2 hours post-administration)
Half-Life	Approximately 1–2 hours (varies by species)
Excretion Pathway	Kidneys (primary), biliary route, and milk
Withdrawal Period	Cattle and Pigs: 28 days Milk: 4 hours
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Packaging	100 ml/bottle
Shelf Life	3 years

Adverse Reactions and Precautions

While Amoxicillin Injection is generally safe, it is essential to adhere to the following guidelines:

• Hypersensitivity: Avoid use in animals with a known allergy to β-lactam antibiotics.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Milk Withdrawal: Milk for human consumption must be discarded for 4 hours post-treatment and 96 hours for cattle.
• Storage: Keep the product sealed and away from light to maintain potency.

Expert Endorsements and Regulatory Standards

The efficacy and safety of Amoxicillin Injection align with the standards set by authoritative bodies such as the National Institute of Standards and Technology (NIST). While specific NIST references for this product are not available, NIST's role in establishing measurement standards for pharmaceuticals underscores the importance of rigorous testing and quality control in drug development. For more information on NIST's contributions to medical science, visit their official website: NIST.gov.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective solution for managing bacterial infections in veterinary medicine. Its broad-spectrum activity, favorable pharmacokinetic profile, and adherence to safety standards make it an indispensable tool for livestock health. By following proper administration guidelines and withdrawal periods, veterinarians can ensure optimal outcomes for animals and consumers alike.

References

1. NIST (National Institute of Standards and Technology): https://www.nist.gov
2. Shijiazhuang Shimu Pharmaceutical Co., Ltd.: https://www.skyvetpharm.com
3. Product Specifications: Amoxicillin Injection (150 mg/ml) – Product Page