Amoxicillin Injection-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Broad-spectrum Antibiotic&Veterinary Use

Introduction

Amoxicillin Injection is a critical veterinary antibiotic used to treat a wide range of bacterial infections in livestock. As a semisynthetic penicillin, it belongs to the amino-penicillin family and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection is a sterile solution containing 150 mg of amoxicillin per milliliter. It is formulated for intramuscular administration and is widely used in veterinary medicine to combat bacterial infections in cattle and pigs. The product’s composition and pharmacological profile make it a reliable choice for treating respiratory diseases caused by pathogens such as Mannheimia haemolytica and Pasteurella multocida.

Shijiazhuang Shimu Pharmaceutical Co., Ltd., based in China, is a trusted manufacturer of veterinary pharmaceuticals. With a focus on quality and innovation, the company ensures that its products meet stringent safety and efficacy standards. Their commitment to research and development has positioned them as a key player in the global veterinary pharmaceutical market.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic use. Here are the key parameters:

• Cmax (Maximum Concentration): In cattle, Cmax reaches 3.45 µg/ml within 2.45 hours post-administration. In pigs, it reaches 3.54 µg/ml after 2 hours.
• Distribution: Amoxicillin is primarily distributed in the extracellular compartment, with a low plasma protein binding rate (17%). It effectively penetrates pulmonary, pleural, and bronchial tissues, as well as pleural and synovial fluids.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Amoxicillin is mainly excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk.

These properties ensure that the drug achieves therapeutic concentrations in target tissues, making it effective against bacterial infections.

Applications in Veterinary Medicine

Amoxicillin Injection is indicated for the treatment of infections caused by Gram-positive and Gram-negative bacteria. Its primary applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common in cattle and pigs.
• Systemic Infections: Treats bacterial infections in various organs and tissues, including the lungs, joints, and udders.
• Post-Surgical Prophylaxis: Prevents bacterial infections following surgical procedures in livestock.

The drug’s time-dependent action and broad-spectrum activity make it a versatile choice for veterinarians. For more details on its uses, visit the product page.

Safety and Adverse Reactions

While Amoxicillin Injection is generally safe, it is not without risks. Adverse reactions may include:

• Hypersensitivity Reactions: Allergic reactions, including anaphylaxis, may occur in animals with a known allergy to β-lactams.
• Local Reactions: Transient injection site reactions, such as swelling or irritation, may occur.

Special Warnings: Shake the vial well before use. Milk from treated animals should not be used for human consumption during treatment. For cattle, milk can be safely consumed 96 hours after the last dose.

The withdrawal period is 28 days for meat and 4 hours for milk, ensuring residues are minimized before animal products enter the food supply.

Storage and Shelf Life

To maintain the efficacy of Amoxicillin Injection, proper storage is crucial:

• Storage Conditions: Keep the product sealed and protected from light. Store in a cool, dry place away from children.
• Shelf Life: The product has a shelf life of 3 years when stored correctly.
• Packaging: Available in 100 ml bottles, ensuring convenient dosing for large animals.

Product Specifications Table

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, specializing in antibiotics and other essential medications. With a commitment to quality and innovation, the company adheres to international standards for drug production and safety. Their products are designed to meet the diverse needs of livestock health, ensuring effective treatment and minimal adverse effects.

For more information about the company’s mission and products, visit their official website.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in cattle and pigs. Its favorable pharmacokinetic profile, broad-spectrum activity, and safety precautions make it a trusted choice among veterinarians. As Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to innovate, they remain dedicated to advancing animal health and welfare.

References

1. National Institute of Standards and Technology (NIST). "Driving Innovation." NIST, 2025. Retrieved from https://www.nist.gov.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd.. "Amoxicillin Injection Product Page." Skyvetpharm, 2025. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html.