Amoxicillin Injection-Veterinary Antibiotic|Broad-Spectrum Treatment

Amoxicillin Injection is a critical veterinary antibiotic formulated to combat bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product represents a significant advancement in veterinary medicine, offering a broad-spectrum solution for respiratory diseases in cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, applications, and the company's commitment to quality and innovation.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic that belongs to the amino-penicillin family. It is specifically designed to target both Gram-positive and Gram-negative bacteria, making it a versatile choice for treating infections in livestock. The product is available in a 100ml bottle with a shelf life of 3 years, ensuring long-term usability for veterinary professionals.

Key Features

• Active Against Respiratory Pathogens: Effective against Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Pharmacokinetic Efficiency: Rapid absorption and distribution in the body, with peak plasma concentrations achieved within 2-2.45 hours post-administration.
• Minimal Protein Binding: Low plasma protein binding (17%) allows for widespread tissue distribution, including pulmonary and synovial fluids.
• Short Withdrawal Period: 28 days for meat and 4 hours for milk, ensuring compliance with food safety standards.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for its effective use in veterinary medicine. The drug's behavior in the body is characterized by several key parameters:

1. Absorption

After intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) of 3.45 µg/ml in cattle at 2.45 hours and 3.54 µg/ml in pigs at 2 hours. This rapid absorption ensures quick therapeutic action, making it ideal for acute infections.

2. Distribution

The drug is primarily distributed in the extracellular compartment. Its low plasma protein binding (17%) facilitates diffusion into tissues such as the lungs, pleura, and bronchial tissues. This distribution pattern is critical for targeting respiratory pathogens effectively.

3. Metabolism

In the liver, Amoxicillin undergoes hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%). This metabolic process reduces the drug's activity but ensures safe elimination from the body.

4. Excretion

The primary route of excretion is through the kidneys in its active form. A secondary route involves the biliary system and milk, which is why strict withdrawal periods are necessary for milk-producing animals.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice for treating bacterial infections in cattle and pigs. Its broad-spectrum activity makes it suitable for a variety of conditions, including:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease (BRD) and swine pneumonia.
• Systemic Infections: Treats infections that spread beyond the respiratory tract, such as septicemia and abscesses.
• Post-Surgical Prophylaxis: Prevents bacterial infections following surgical procedures in livestock.

For detailed information on Amoxicillin Injection uses, visit the product page.

Advantages of Amoxicillin Injection

The unique properties of Amoxicillin Injection offer several advantages over other antibiotics in veterinary medicine:

• High Efficacy: Demonstrated effectiveness against a wide range of bacterial pathogens, reducing the need for multiple medications.
• Quick Onset of Action: Rapid absorption ensures that therapeutic levels are achieved quickly, providing prompt relief for infected animals.
• Cost-Effective: Offers a balance between affordability and effectiveness, making it a preferred choice for large-scale livestock management.
• Minimal Side Effects: Generally well-tolerated, with adverse reactions primarily limited to transient local reactions at the injection site.

Product Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Formulation	Injectable Solution
Administration Route	Intramuscular
Withdrawal Period	28 days (meat), 4 hours (milk)
Storage Conditions	Sealed, protected from light, out of reach of children
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality products that meet global standards. With a focus on innovation and research, the company has established itself as a trusted name in the veterinary industry.

For more information about the company's mission and values, visit the Shijiazhuang Shimu Pharmaceutical Co., Ltd. website.

Important Safety Information

While Amoxicillin Injection is generally safe, it is essential to follow the recommended guidelines to ensure the health of both animals and consumers:

• Allergy Precautions: Do not administer to animals with a known allergy to β-lactam antibiotics.
• Injection Site Reactions: Local reactions may occur but are typically transient.
• Milk Safety: Avoid using milk from treated animals for human consumption during the withdrawal period.
• Storage: Keep the product in a cool, dry place away from direct sunlight.

Ensuring Quality and Compliance

Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to rigorous quality control standards to ensure the safety and efficacy of Amoxicillin Injection. The company's commitment to excellence is reflected in its compliance with international veterinary pharmaceutical regulations, as highlighted by the National Institute of Standards and Technology (NIST), which emphasizes the importance of precise measurements and standards in pharmaceutical manufacturing.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective solution for managing bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and adherence to safety standards make it a valuable tool for veterinarians. By choosing this product, practitioners can ensure the health of their patients while maintaining compliance with food safety regulations.

References

1. National Institute of Standards and Technology (NIST). "Standards and Measurements." Retrieved from https://www.nist.gov

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. "Amoxicillin Injection Product Information." Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html