Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic & Broad-Spectrum Treatment

Amoxicillin Injection, developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a broad-spectrum antibiotic widely used in veterinary medicine to treat bacterial infections in livestock. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, application scenarios, and the company's expertise in pharmaceutical innovation.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin belongs to the amino-penicillin family and is structurally similar to ampicillin. As a bactericidal agent, it effectively targets both Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis. The drug is particularly effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs.

Key pharmacokinetic data highlights its rapid absorption and distribution. In cattle, the maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved within 2.45 hours after intramuscular administration. Similarly, in pigs, the Cmax of 3.54 µg/ml is reached in 2 hours. Amoxicillin's low plasma protein binding (17%) allows it to distribute efficiently into extracellular compartments, including pulmonary, pleural, and bronchial tissues. It also diffuses into pleural and synovial fluids, making it suitable for treating infections in these areas.

Metabolism occurs primarily in the liver, where the β-lactam ring is hydrolyzed to form inactive penicilloic acid. The drug is excreted mainly via the kidneys, with a smaller portion eliminated through the biliary route and milk. This distribution profile ensures sustained therapeutic levels in target tissues.

Technical Specifications and Formulation

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indications	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage Conditions	Seal, protect from light, and keep out of reach of children
Packaging	100ml/bottle
Shelf Life	3 years

Application Scenarios in Veterinary Medicine

Amoxicillin Injection is a critical tool in managing bacterial infections in livestock. Its efficacy against Pasteurella multocida and Mannheimia haemolytica makes it a first-line treatment for respiratory diseases in cattle and pigs. The drug's ability to achieve therapeutic concentrations in lung tissues and pleural fluid ensures it addresses both localized and systemic infections.

Due to its rapid onset of action and favorable pharmacokinetics, Amoxicillin Injection is commonly used in large-scale farming operations. It is particularly valuable in preventing and treating conditions such as pneumonia, mastitis, and septicemia, which can significantly impact animal health and productivity.

Advantages and Safety Considerations

One of the key advantages of Amoxicillin Injection is its broad-spectrum activity, which reduces the need for multiple antibiotics. Its time-dependent mechanism of action ensures that consistent drug levels in the bloodstream are maintained, enhancing its antibacterial efficacy.

However, users must adhere to safety guidelines. As with all β-lactam antibiotics, hypersensitivity reactions are possible, and it should not be administered to animals with a known allergy to penicillins. Local reactions at the injection site may occur but are typically transient. The product also includes specific warnings about milk withdrawal periods, emphasizing the importance of following guidelines to ensure food safety.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, committed to developing high-quality antibiotics and treatments for livestock. With a focus on innovation and compliance, the company ensures its products meet stringent quality standards. Their expertise in formulating antibiotics like Amoxicillin Injection reflects their dedication to improving animal health and supporting the agricultural sector.

The company's products are widely used in veterinary practices across China and beyond, underscoring their reputation for reliability and efficacy. By leveraging advanced research and development, Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to contribute to the advancement of veterinary medicine.

References and Authoritative Citations

For further information on antimicrobial resistance and veterinary drug standards, refer to the National Institute of Standards and Technology (NIST): https://www.nist.gov/. NIST provides critical resources on measurement science and standards, which are essential for ensuring the accuracy and reliability of pharmaceutical products.

Additional details on antibiotic use in livestock can be found in the NIST Antimicrobial Resistance Research initiative.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital solution for managing bacterial infections in livestock. Its robust pharmacokinetic profile, broad-spectrum activity, and adherence to safety standards make it a trusted choice for veterinarians. By understanding its technical specifications and application scenarios, stakeholders can optimize its use to enhance animal health and productivity.

For more information, visit the official product page: Amoxicillin Injection Product Page.