Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic, Bacterial Infections

Amoxicillin Injection is a critical veterinary pharmaceutical product designed to combat bacterial infections in livestock. As a broad-spectrum antibiotic, it plays a vital role in maintaining animal health and productivity. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and the company behind its development, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Understanding Amoxicillin Injection

Amoxicillin is a semisynthetic penicillin antibiotic with a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. It belongs to the amino-penicillin family, sharing structural similarities with ampicillin. The drug functions as a bactericide by inhibiting the synthesis and repair of bacterial cell walls through the disruption of mucopeptide formation. This mechanism makes it particularly effective against pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs.

As a time-dependent antibiotic, Amoxicillin Injection requires consistent plasma concentrations to achieve optimal therapeutic effects. Its efficacy is closely tied to the duration of exposure to the bacteria rather than peak concentrations. This characteristic underscores the importance of adhering to prescribed dosing schedules for maximum effectiveness.

Pharmacokinetic Properties

Understanding how Amoxicillin Injection is absorbed, distributed, metabolized, and excreted is essential for its proper application in veterinary medicine. Here's a detailed breakdown of its pharmacokinetic profile:

• Peak Concentration (Cmax): In cattle, Cmax of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration. In pigs, the peak concentration reaches 3.54 µg/ml within 2 hours.
• Distribution: Amoxicillin is predominantly distributed in the extracellular compartment, facilitated by its low plasma protein binding (17%). It effectively reaches tissues such as the lungs, pleura, and bronchial tissues, where it maintains concentrations similar to plasma levels. The drug also diffuses into pleural, synovial, and lymphatic tissues.
• Metabolism: The liver metabolizes Amoxicillin via hydrolysis of the β-lactam ring, producing an inactive metabolite called penicilloic acid (20% of the administered dose).
• Excretion: The primary route of excretion is through the kidneys in its active form. Secondary excretion occurs via the biliary system and milk, highlighting the importance of monitoring withdrawal periods for dairy animals.

Applications in Veterinary Medicine

Amoxicillin Injection is specifically indicated for treating infections caused by susceptible bacteria in livestock. Its applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which are major pathogens in bovine and porcine respiratory diseases.
• Systemic Infections: Broad-spectrum activity makes it suitable for treating a range of bacterial infections, including those affecting the skin, urinary tract, and gastrointestinal system.
• Preventive Use: In some cases, it may be used prophylactically to prevent secondary bacterial infections following viral outbreaks or surgical procedures.

Safety and Adverse Reactions

While Amoxicillin Injection is generally safe, it is not without risks. Adverse reactions may include:

• Hypersensitivity Reactions: As with all β-lactam antibiotics, allergic reactions can occur in animals with a known sensitivity to penicillins. Immediate veterinary attention is required if signs of anaphylaxis (e.g., swelling, difficulty breathing) are observed.
• Local Reactions: Transient injection site reactions, such as swelling or redness, may occur but typically resolve without intervention.

Important Warnings: Shake the solution well before use. Milk from treated animals must not be used for human consumption during treatment. For cattle, milk can only be safely used 96 hours after the last dose.

Withdrawal Periods and Storage

Proper adherence to withdrawal periods is crucial to ensure the safety of animal-derived products for human consumption:

• Cattle and Pigs: 28 days
• Milk: 4 hours

Storage instructions are as follows:

• Keep the product sealed and protected from light.
• Store in a cool, dry place, out of reach of children.
• Packaging: 100ml/bottle
• Shelf Life: 3 years

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Indications	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Peak Concentration (Cmax)	Cattle: 3.45 µg/ml (2.45 hours post-administration); Pigs: 3.54 µg/ml (2 hours post-administration)
Withdrawal Period	Cattle and Pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and stored out of reach of children
Shelf Life	3 years

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals based in China. The company specializes in developing high-quality antibiotics and other veterinary products to support animal health and agricultural productivity. With a focus on innovation and compliance with international standards, Shijiazhuang Shimu has established itself as a trusted partner for farmers and veterinarians worldwide.

For more information about the company's mission and product portfolio, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Conclusion

Amoxicillin Injection is an indispensable tool in veterinary medicine, offering a reliable solution for bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and established safety record make it a preferred choice for treating respiratory and systemic infections in cattle and pigs. By adhering to proper dosing, withdrawal periods, and storage guidelines, veterinarians and farmers can ensure the effectiveness and safety of this critical pharmaceutical product.

For detailed specifications and usage instructions, refer to the Amoxicillin Injection product page.

References

While no direct citations from NIST were found in the provided context, the pharmacokinetic data and safety guidelines align with general veterinary pharmacology principles. For further information on pharmaceutical standards, consult authoritative sources such as the U.S. Food and Drug Administration (FDA) or World Organisation for Animal Health (WOAH).