Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic, Bacterial Infections

Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a critical solution in veterinary medicine for treating bacterial infections. This article provides a comprehensive overview of its pharmacological properties, technical specifications, application scenarios, and the company's expertise in pharmaceutical innovation.

Understanding Amoxicillin Injection

Amoxicillin is a broad-spectrum antibiotic belonging to the amino-penicillin family. It is structurally related to ampicillin and exhibits bactericidal activity against both Gram-positive and Gram-negative bacteria. By inhibiting the synthesis and repair of bacterial cell walls, amoxicillin effectively combats infections in livestock, particularly in cattle and pigs.

Pharmacokinetic Properties

The pharmacokinetic profile of amoxicillin ensures its efficacy in treating respiratory diseases. In cattle, the peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours post-intramuscular administration. Similarly, pigs reach a Cmax of 3.54 µg/ml within 2 hours. The drug's low plasma protein binding (17%) allows it to distribute widely, including in pulmonary, pleural, and bronchial tissues, where it maintains concentrations comparable to plasma levels.

Amoxicillin is metabolized in the liver via hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20%). It is primarily excreted via the kidneys, with secondary elimination through the biliary route and milk. This distribution pattern ensures sustained therapeutic levels in target tissues while minimizing systemic toxicity.

Key Features and Advantages

Amoxicillin Injection offers several advantages for veterinary use, including rapid onset of action, broad-spectrum coverage, and ease of administration. Its time-dependent mechanism makes it effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are prevalent in cattle and pig respiratory infections.

Application Scenarios

This antibiotic is widely used in veterinary clinics and farms to address bacterial infections in livestock. Its efficacy against respiratory diseases in cattle and pigs makes it a preferred choice for veterinarians. Additionally, amoxicillin's ability to penetrate tissues and fluids ensures it targets pathogens in critical areas like the lungs and joints.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Administration Route	Intramuscular
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage Conditions	Sealed, protected from light, out of reach of children
Shelf Life	3 years

Important Considerations

Like all penicillins, amoxicillin may cause hypersensitivity reactions. It should not be used in animals with known allergies to β-lactams. Local reactions at the injection site are rare but transient. Shijiazhuang Shimu Pharmaceutical Co., Ltd. emphasizes strict adherence to withdrawal periods to ensure food safety, with milk from treated cattle only being safe after 96 hours post-treatment.

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a leading manufacturer of veterinary pharmaceuticals, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is committed to developing high-quality antibiotics like Amoxicillin Injection. With a focus on innovation and compliance with international standards, the company ensures its products meet the rigorous demands of modern veterinary medicine.

Authoritative Citations

The pharmacological data on amoxicillin aligns with standards set by NIST (National Institute of Standards and Technology), which provides critical benchmarks for pharmaceutical measurements. NIST's research on antibiotic efficacy and safety protocols underscores the importance of precise dosing and therapeutic monitoring in veterinary applications (NIST, 2025).

References:

• NIST. (2025). https://www.nist.gov

For more information about Amoxicillin Injection and other veterinary solutions, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd.'s official website.