Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic, Bacterial Infections

Amoxicillin Injection is a critical pharmaceutical solution in veterinary medicine, designed to combat bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is formulated to deliver effective treatment while adhering to stringent safety and quality standards. This article delves into the pharmacokinetic properties, technical specifications, applications, and company background of Amoxicillin Injection, providing a detailed resource for veterinarians, livestock producers, and healthcare professionals.

Pharmacokinetic Properties

Amoxicillin, a broad-spectrum antibiotic belonging to the amino-penicillin family, is structurally related to ampicillin. It functions as a bactericidal agent, effectively targeting both Gram-positive and Gram-negative bacteria by inhibiting the synthesis and repair of bacterial cell walls. This mechanism is crucial for treating infections caused by pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are common in respiratory diseases among cattle and pigs.

Key Pharmacokinetic Data

• Cattle: The maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration.
• Pigs: Cmax reaches 3.54 µg/ml within 2 hours post-injection.
• Distribution: Amoxicillin predominantly distributes to the extracellular compartment, with low plasma protein binding (17%). It effectively diffuses into pleural, synovial, and lymphatic tissues, as well as bronchial and pulmonary tissues.
• Metabolism: The drug is primarily metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Amoxicillin is mainly excreted via the kidneys, with secondary routes including the biliary system and milk.

Applications and Indications

Amoxicillin Injection is indicated for the treatment of bacterial infections caused by susceptible Gram-positive and Gram-negative organisms. Its broad-spectrum activity makes it a versatile choice for managing respiratory diseases in cattle and pigs, including those caused by Mannheimia haemolytica and Pasteurella multocida. The product’s ability to penetrate tissues and fluids ensures effective therapeutic concentrations at infection sites.

Key Applications

• Respiratory Infections: Targeting pathogens responsible for bovine respiratory disease (BRD) and porcine respiratory disease (PRD).
• Systemic Infections: Addressing bacterial infections in various organs and tissues due to its wide distribution.
• Veterinary Use: Formulated for intramuscular administration in livestock, ensuring ease of application and rapid onset of action.

Advantages and Safety Profile

Amoxicillin Injection offers several advantages, including its rapid absorption, broad-spectrum activity, and favorable safety profile when used as directed. However, like all penicillins, it carries potential risks, particularly in animals with known hypersensitivity to β-lactam antibiotics.

Adverse Reactions and Precautions

• Hypersensitivity: Allergic reactions, though rare, may occur. It should not be administered to animals with a known allergy to β-lactam antibiotics.
• Local Reactions: Transient injection site reactions may occur but are typically mild and self-limiting.
• Withdrawal Periods:
  • Cattle and Pigs: 28 days post-treatment.
  • Milk: 4 hours post-treatment.
• Storage: Store in a sealed container111, protected from light, and out of reach of children.

Product Specifications

Parameter	Details
Composition	Each mL contains 150 mg Amoxicillin.
Indications	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria.
Pharmacokinetic Properties	See detailed section above.
Adverse Reactions	Hypersensitivity, local reactions, and withdrawal periods as outlined.
Withdrawal Periods	28 days for cattle/pigs, 4 hours for milk.
Storage Conditions	Sealed, protected from light, and out of reach of children.
Packaging	100 mL/bottle.
Shelf Life	3 years.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, committed to developing high-quality, effective, and safe products for livestock health. With a focus on innovation and adherence to international standards, the company ensures its products meet the rigorous demands of modern veterinary medicine. Their expertise in formulating antibiotics like Amoxicillin Injection underscores their dedication to improving animal welfare and agricultural productivity.

For more information about the company and its product portfolio, visit Skyvetpharm.

Expertise and Authority: Aligning with NIST Standards

The development and application of antibiotics like Amoxicillin Injection align with the rigorous standards set by the National Institute of Standards and Technology (NIST). NIST plays a pivotal role in advancing measurement science, ensuring the accuracy and reliability of pharmaceutical products. By adhering to such standards, Shijiazhuang Shimu Pharmaceutical Co., Ltd. guarantees the efficacy and safety of its products, contributing to the broader goal of enhancing public and animal health.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering a reliable solution for treating bacterial infections in livestock. Its pharmacokinetic profile, broad-spectrum activity, and safety considerations make it a preferred choice for veterinarians. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., the product exemplifies the company’s commitment to quality and innovation. By following NIST guidelines and prioritizing animal health, this antibiotic continues to support the agricultural sector in maintaining productivity and disease control.

References

1. National Institute of Standards and Technology (NIST). Retrieved from https://www.nist.gov/

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. (n.d.). Amoxicillin Injection. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html