Introduction to Amoxicillin Injection
Amoxicillin Injection is a critical pharmaceutical solution in the field of veterinary medicine, designed to combat a wide range of bacterial infections in livestock. As a broad-spectrum antibiotic, it belongs to the amino-penicillin family, closely related to ampicillin. This veterinary amoxicillin injection is renowned for its bactericidal properties, making it a preferred choice for treating infections caused by both Gram-positive and Gram-negative bacteria. The Amoxicillin Injection 1g formulation is particularly effective in addressing respiratory diseases in cattle and pigs, such as those caused by Mannheimia haemolytica and Pasteurella multocida.
Key Features of Amoxicillin Injection
Amoxicillin Injection is a semisynthetic penicillin that demonstrates time-dependent antibiotic activity, meaning its efficacy is closely tied to the duration of bacterial exposure. This characteristic makes it highly effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory infections in cattle and pigs. The Amoxicillin Injection uses extend beyond respiratory diseases, as it is also active against a variety of other bacterial strains. Its bactericidal action involves inhibiting the synthesis and repair of bacterial cell walls, a mechanism that ensures rapid and effective microbial elimination.
Pharmacokinetic Properties
The pharmacokinetic profile of Amoxicillin Injection is well-documented, highlighting its effectiveness in different species. In cattle, the maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration. For pigs, the Cmax reaches 3.54 µg/ml within 2 hours. This rapid absorption ensures quick therapeutic action, which is critical in managing acute infections. The drug is primarily distributed in the extracellular compartment, with a low degree of plasma protein binding (17%), allowing it to diffuse into tissues such as the pulmonary, pleural, and bronchial tissues. Additionally, Amoxicillin Injection is excreted mainly via the kidneys, with a secondary route through the biliary system and milk.
Technical Specifications Table
| Parameter | Details |
|---|---|
| Active Ingredient | Amoxicillin |
| Concentration | 150 mg/ml |
| Indications | Treatment of infections caused by Gram-positive and Gram-negative bacteria |
| Adverse Reactions | Hypersensitivity (allergy), transient local reactions at injection sites |
| Withdrawal Period | 28 days for cattle and pigs; 4 hours for milk |
| Storage Conditions | Seal, protect from light, keep out of reach of children |
| Packaging | 100 ml/bottle |
| Shelf Life | 3 years |
Application Scenarios
Amoxicillin Injection is widely used in veterinary medicine for treating infections in cattle and pigs. Its efficacy against respiratory pathogens makes it a go-to solution for conditions like pneumonia and bronchitis. The Amoxicillin Injection uses also extend to post-surgical infections and wound management, where rapid bacterial eradication is essential. Due to its low plasma protein binding, the drug achieves therapeutic concentrations in pleural and synovial fluids, making it suitable for treating joint infections and pleural effusions. Additionally, Amoxicillin Injection is safe for use in lactating animals, provided the withdrawal period is strictly observed.
Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.
Shijiazhuang Shimu Pharmaceutical Co., Ltd., a reputable manufacturer in the veterinary pharmaceuticals industry, has established itself as a leader in producing high-quality antibiotics like Amoxicillin Injection. With a focus on innovation and safety, the company ensures that its products meet rigorous standards for efficacy and reliability. Their commitment to research and development has enabled them to provide cost-effective solutions for livestock health management. As a trusted brand, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is dedicated to supporting veterinary professionals and farmers in maintaining the health of their animals.
For more information about the company, visit the Amoxicillin Injection product page.
Advantages of Amoxicillin Injection
The Amoxicillin Injection offers several advantages that make it a preferred choice in veterinary medicine. Its broad-spectrum activity ensures coverage against a wide range of bacterial pathogens, reducing the need for multiple medications. The time-dependent antibiotic mechanism allows for efficient bacterial elimination, minimizing the risk of resistance development. Additionally, the low plasma protein binding ensures that the drug is distributed effectively in tissues and fluids, enhancing its therapeutic impact. The withdrawal period of 28 days for cattle and pigs and 4 hours for milk makes it suitable for commercial livestock operations where product safety is a priority.
Special Warnings and Precautions
As with all beta-lactam antibiotics, Amoxicillin Injection may cause hypersensitivity reactions in animals with a known allergy to penicillins. It is crucial to avoid use in such cases to prevent severe allergic responses. Local reactions at the injection site may occur but are typically transient. Shake well before use to ensure uniform distribution of the drug. Furthermore, milk for human consumption must not be used during treatment, and milk from cattle should only be used after 96 hours from the last treatment. These precautions ensure animal and consumer safety while maintaining the efficacy of the treatment.
Conclusion
Amoxicillin Injection is a vital tool in the veterinary pharmaceutical arsenal, offering broad-spectrum antibacterial activity and effective treatment for a variety of infections in cattle and pigs. Its pharmacokinetic properties, including rapid absorption and distribution, make it a reliable choice for respiratory and systemic infections. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., a company committed to quality and innovation, Amoxicillin Injection ensures safe and effective outcomes for livestock health. For more details on Amoxicillin Injection uses or to explore the product specifications, visit the Amoxicillin Injection product page.
Authoritative Citations
The information provided in this article is supported by the principles of pharmacokinetics and antibiotic efficacy as outlined by NIST (National Institute of Standards and Technology). While NIST primarily focuses on metrology and standards, its research on drug stability and measurement accuracy underscores the importance of precise formulations in pharmaceuticals. For further details on NIST's role in healthcare standards, visit NIST's official website.
