Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic, Broad-Spectrum Efficacy

Amoxicillin Injection, a critical pharmaceutical product in veterinary medicine, is designed to combat bacterial infections in livestock. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is widely recognized for its efficacy and safety profile. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety considerations, and the company's commitment to quality.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic that belongs to the amino-penicillin family. It is specifically formulated for veterinary use to treat infections caused by both Gram-positive and Gram-negative bacteria. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly.

Key Specifications:

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable Solution
Packaging	100ml/bottle
Shelf Life	3 years
Withdrawal Period	28 days (Cattle and Pigs), 4 hours (Milk)

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic use. The drug exhibits time-dependent antibacterial activity, making it effective against a broad spectrum of pathogens.

Absorption and Distribution

Following intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) within 2-2.45 hours in cattle and 2 hours in pigs. Its low plasma protein binding (17%) facilitates widespread distribution, including in pulmonary, pleural, and bronchial tissues. The drug also diffuses into pleural, synovial, and lymphatic tissues, ensuring effective targeting of infection sites.

Metabolism and Excretion

Amoxicillin is primarily metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%). The majority of the drug is excreted unchanged via the kidneys, with secondary excretion through the biliary route and milk. This excretion profile necessitates careful monitoring in lactating animals.

Applications in Veterinary Medicine

Amoxicillin Injection is indicated for the treatment of respiratory infections in cattle and pigs caused by specific pathogens. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a preferred choice for managing bovine and porcine respiratory diseases.

Key Applications:

• Treatment of respiratory infections in cattle
• Management of Pasteurella multocida infections in pigs
• Supportive therapy for bacterial infections in livestock

Safety and Adverse Reactions

While Amoxicillin Injection is generally well-tolerated, it is crucial to adhere to safety guidelines to minimize risks. As with all β-lactam antibiotics, hypersensitivity reactions may occur in animals with known allergies to penicillins.

Adverse Reactions:

• Hypersensitivity (allergic) reactions
• Transient local reactions at the injection site

Precautions:

• Shake the solution well before use
• Do not use in animals with a history of β-lactam allergy
• Restrict milk from treated animals for 4 hours post-administration

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality products for animal health. With a focus on innovation and compliance, the company adheres to stringent quality control standards to ensure the safety and efficacy of its medications.

As a trusted name in the industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. collaborates with veterinary professionals to develop solutions that meet the evolving needs of livestock management. Their commitment to research and development is reflected in products like Amoxicillin Injection, which combines scientific rigor with practical application.

Regulatory Compliance and Standards

Amoxicillin Injection complies with national and international standards for veterinary pharmaceuticals. The product undergoes rigorous testing to ensure it meets specifications for potency, purity, and safety. The National Institute of Standards and Technology (NIST) plays a critical role in establishing measurement standards that underpin the quality of pharmaceutical products. While NIST does not directly regulate veterinary medications, its work in metrology and analytical standards supports the accuracy of testing procedures used in drug development and quality control.

References:

National Institute of Standards and Technology (NIST). (n.d.). Retrieved from https://www.nist.gov/

Conclusion

Amoxicillin Injection remains a cornerstone in the treatment of bacterial infections in veterinary medicine. Its favorable pharmacokinetic profile, broad-spectrum activity, and established safety record make it an invaluable tool for livestock health management. For more information on amoxicillin injection and its applications, visit the product page or explore the company's website.

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