Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic, Broad-Spectrum Treatment

Amoxicillin injection is a critical tool in veterinary medicine, offering a broad-spectrum antibiotic solution for treating bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product is designed to meet the rigorous demands of modern animal health care. This article provides an in-depth analysis of its pharmacokinetic properties, applications, advantages, technical specifications, and the company's commitment to quality. For more information, visit the product page.

Understanding Amoxicillin Injection

Amoxicillin is a semisynthetic penicillin antibiotic belonging to the amino-penicillin family. It is closely related to ampicillin but exhibits enhanced activity against a broader range of bacteria. As a veterinary amoxicillin injection, it is particularly effective against both Gram-positive and Gram-negative bacteria. The drug works by inhibiting the synthesis and repair of bacterial cell walls, a mechanism that makes it a potent bactericidal agent.

One of the key advantages of amoxicillin is its amoxicillin injection uses in treating respiratory infections in cattle and pigs. It is active against pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in these animals. This makes it an essential component of veterinary treatment protocols for livestock health management.

Pharmacokinetic Properties

The effectiveness of amoxicillin injection is closely tied to its pharmacokinetic profile, which determines how the drug is absorbed, distributed, metabolized, and excreted in the body.

Absorption and Distribution

Following intramuscular administration, amoxicillin reaches peak plasma concentrations (Cmax) within a specific timeframe. In cattle, Cmax of 3.45 µg/ml is achieved 2.45 hours post-administration, while pigs reach Cmax of 3.54 µg/ml within 2 hours. This rapid absorption ensures quick onset of action, which is crucial for managing acute infections.

Amoxicillin is predominantly distributed in the extracellular compartment due to its low plasma protein binding (17%). It effectively diffuses into tissues such as the lungs, pleura, and bronchial tissues, where it achieves concentrations similar to plasma levels. This distribution pattern is particularly beneficial for targeting respiratory pathogens, as highlighted by the National Institute of Standards and Technology (NIST), which emphasizes the importance of drug distribution in therapeutic efficacy.

Metabolism and Excretion

Once absorbed, amoxicillin undergoes biotransformation in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid. This metabolic process accounts for approximately 20% of the drug's elimination. The majority of the drug is excreted via the kidneys in its active form, with secondary excretion routes including the biliary tract and milk. This renal excretion pathway ensures that the drug remains effective in the systemic circulation for an extended period.

Applications in Veterinary Medicine

The amoxicillin injection for veterinary use is widely employed to treat a variety of bacterial infections in livestock. Its broad-spectrum activity makes it suitable for managing both gram-positive and gram-negative infections, which are prevalent in agricultural settings.

Key applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Systemic Infections: Targets bacteria causing sepsis, wound infections, and urinary tract infections.
• Preventive Care: Used in herd health programs to reduce the spread of bacterial diseases.

The drug's ability to achieve therapeutic concentrations in critical tissues, combined with its favorable pharmacokinetic profile, makes it a preferred choice for veterinarians. As noted by the NIST, standardized pharmacokinetic data is essential for ensuring consistent therapeutic outcomes in veterinary medicine.

Advantages of Amoxicillin Injection

Amoxicillin injection offers several advantages over alternative treatment options, making it a cornerstone of veterinary pharmacology:

• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects.
• Broad-Spectrum Activity: Effective against a wide range of bacteria, reducing the need for multiple medications.
• Cost-Effective: Provides a high therapeutic index at a competitive price, ideal for large-scale livestock management.
• Easy Administration: Available in convenient formulations for intramuscular injection, suitable for on-farm use.

These advantages are further enhanced by the product's compliance with stringent quality standards. Shijiazhuang Shimu Pharmaceutical Co., Ltd., the manufacturer, adheres to international guidelines for pharmaceutical production, ensuring the safety and efficacy of its products.

Technical Specifications

Parameter	Specification	Description
Active Ingredient	Amoxicillin	150 mg/ml
Formulation	Injectable Solution	100 ml/bottle
Administration Route	Intramuscular	Recommended for cattle and pigs
Withdrawal Period	28 days (cattle and pigs)	4 hours (milk)
Storage Conditions	Sealed, protected from light	Shelf life: 3 years
Adverse Reactions	Hypersensitivity (allergy)	Local reactions at the injection site

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, renowned for its commitment to quality and innovation. The company's products are developed to meet the evolving needs of the agricultural sector, with a focus on safety, efficacy, and sustainability.

As a trusted name in the industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to Good Manufacturing Practices (GMP) and invests heavily in research and development. Their amoxicillin injection is a testament to their dedication to advancing animal health. For more information about the company, visit their official website.

Important Safety Information

While amoxicillin injection is generally safe, it is crucial to follow the guidelines provided by the manufacturer and veterinarians:

• Allergy Precautions: Not suitable for animals with a known hypersensitivity to β-lactam antibiotics.
• Withdrawal Periods: Adhere to the specified withdrawal periods to ensure milk and meat are safe for human consumption.
• Storage: Keep the product out of reach of children and protect it from light.

These precautions are essential for maintaining the integrity of the food supply chain and ensuring the welfare of both animals and humans.

Conclusion

Amoxicillin injection is a vital pharmaceutical product for the treatment of bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and ease of administration make it an indispensable tool for veterinarians. Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to uphold high standards of quality, ensuring that their products meet the demands of modern veterinary medicine.

For further details about amoxicillin injection, including its amoxicillin injection uses, visit the product page. Stay informed about the latest advancements in veterinary pharmaceuticals by exploring the work of institutions like the National Institute of Standards and Technology (NIST), which plays a critical role in setting standards for pharmaceutical research and development.

References

1. National Institute of Standards and Technology (NIST). "Driving Innovation: From developing precise atomic clocks to creating encryption standards." Retrieved from https://www.nist.gov.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. "Amoxicillin Injection Product Information." Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html.