Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic,Broad-Spectrum Treatment

Introduction

Amoxicillin Injection is a widely used antibiotic in veterinary medicine, known for its efficacy against a broad spectrum of bacterial infections. As a semisynthetic penicillin, it belongs to the amino-penicillin family and is structurally related to ampicillin. This article provides an in-depth analysis of the product's pharmacokinetic properties, technical specifications, applications, and safety profile, along with insights into the company behind it, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection is a sterile solution designed for intramuscular administration in livestock. It contains Amoxicillin 150mg per ml, making it suitable for treating infections caused by both Gram-positive and Gram-negative bacteria. The product is packaged in 100ml bottles, with a shelf life of 3 years when stored properly. Its formulation ensures rapid absorption and effective distribution throughout the body, as detailed in the following sections.

Pharmacokinetic Properties

Amoxicillin is a time-dependent antibiotic that exerts its bactericidal effects by inhibiting the synthesis and repair of bacterial cell walls. It is particularly effective against pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs. The drug's pharmacokinetics are well-documented, with key parameters outlined below:

Key Pharmacokinetic Data

• Cattle: Peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours post-administration.
• Pigs: Cmax of 3.54 µg/ml is reached 2 hours after intramuscular injection.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with minimal plasma protein binding (17%). It reaches therapeutic levels in lung, pleural, and bronchial tissues, as well as pleural and synovial fluids.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the dose).
• Excretion: Approximately 60-80% of the drug is excreted unchanged via the kidneys, with secondary excretion through the biliary route and milk.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Sterile Injection Solution
Administration Route	Intramuscular
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage Conditions	Sealed, protected from light, out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle

Applications in Veterinary Medicine

Amoxicillin Injection is a critical tool in managing bacterial infections in livestock. Its broad-spectrum activity makes it suitable for treating respiratory diseases, which are a significant cause of economic loss in the agricultural sector. Specific applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica in cattle and Pasteurella multocida in pigs.
• Systemic Infections: Treats bacterial infections affecting multiple organs, including skin, joints, and the respiratory tract.
• Preventive Use: May be used prophylactically in high-risk environments to prevent bacterial outbreaks.

Advantages of Amoxicillin Injection

The product offers several advantages that make it a preferred choice in veterinary medicine:

• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects.
• High Bioavailability: Intramuscular administration allows for efficient systemic delivery.
• Cost-Effective: Provides a balance between efficacy and affordability for large-scale use.
• Wide Spectrum of Activity: Effective against a diverse range of pathogens, reducing the need for multiple medications.

Safety and Precautions

While Amoxicillin Injection is generally safe, certain precautions must be observed:

• Allergies: Contraindicated in animals with known hypersensitivity to β-lactam antibiotics.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Milk Withdrawal: Milk from treated animals must not be used for human consumption during treatment and for 4 hours post-treatment.
• Storage: Keep the product in a cool, dry place away from direct sunlight.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medical products. With a focus on innovation and compliance with international standards, the company ensures that its products meet the rigorous demands of the agricultural and veterinary sectors. Their commitment to research and development has positioned them as a trusted partner for livestock health management.

References and Authoritative Sources

For further information on pharmaceutical standards and regulations, the National Institute of Standards and Technology (NIST) provides critical resources on measurement science and quality control. While specific references to NIST in this context could not be retrieved, the principles outlined by NIST in its guidelines emphasize the importance of precise formulations and safety protocols in pharmaceutical production.

Conclusion

Amoxicillin Injection is a vital medication in veterinary medicine, offering effective treatment for a wide range of bacterial infections. Its favorable pharmacokinetic profile, combined with the expertise of Shijiazhuang Shimu Pharmaceutical Co., Ltd., ensures that it remains a reliable solution for livestock health. As with all antibiotics, responsible use is essential to prevent resistance and maintain efficacy for future generations.

Additional Resources

• Product Page: Amoxicillin Injection
• Company Website: Shijiazhuang Shimu Pharmaceutical Co., Ltd.