Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Introduction to Amoxicillin Injection

Amoxicillin Injection is a semisynthetic penicillin antibiotic designed for the treatment of bacterial infections in livestock, particularly cattle and pigs. As a veterinary amoxicillin injection, it plays a vital role in managing respiratory diseases caused by pathogens such as Mannheimia haemolytica and Pasteurella multocida. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, applications, and the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection is a broad-spectrum antibiotic derived from the amino-penicillin family. It is formulated to inhibit bacterial cell wall synthesis, making it effective against both Gram-positive and Gram-negative bacteria. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly. Its primary use in veterinary medicine includes treating respiratory infections in cattle and pigs, as outlined in the amoxicillin injection uses.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is crucial for optimizing its therapeutic efficacy. Here are the key details:

• Cmax (Maximum Plasma Concentration): In cattle, Cmax reaches 3.45 µg/ml 2.45 hours post-intramuscular administration. In pigs, it reaches 3.54 µg/ml within 2 hours.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with low plasma protein binding (17%). It achieves similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma, and diffuses into pleural, synovial, and lymphatic tissues.
• Metabolism: The drug is biotransformed in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Amoxicillin is mainly excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk.

These properties highlight its effectiveness in targeting bacterial infections while maintaining a favorable safety profile for veterinary use.

Technical Specifications

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in the treatment of respiratory diseases in livestock. Its efficacy against specific pathogens includes:

• Cattle: Effective against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease (BRD).
• Pigs: Active against Pasteurella multocida, a primary pathogen in porcine respiratory infections.

Additionally, the product is suitable for managing a range of bacterial infections, including those affecting the skin, urinary tract, and gastrointestinal system. Its amoxicillin injection for veterinary use is designed to ensure rapid and sustained therapeutic levels in target tissues.

Adverse Reactions and Safety Considerations

Like all penicillins, Amoxicillin Injection carries the risk of hypersensitivity reactions, including allergic responses. It should not be administered to animals with a known allergy to β-lactam antibiotics. Common adverse effects include:

• Local Reactions: Transient injection site reactions, such as swelling or redness, may occur.
• Withdrawal Periods: Adherence to withdrawal periods is critical to ensure milk and meat safety for human consumption. For cattle, the withdrawal period is 28 days, while milk must be discarded for 4 hours post-treatment.

Proper storage and handling are essential. The product should be kept in a sealed container111, away from light, and stored at recommended temperatures to maintain potency.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medications for livestock health. With a focus on innovation and compliance with international standards, the company ensures that its products, including the amoxicillin injection 1g, meet stringent quality and safety requirements.

The company's commitment to research and development has enabled it to provide effective solutions for common veterinary challenges, such as bacterial infections in cattle and pigs. Their product portfolio includes a wide range of antibiotics, each tailored to address specific clinical needs.

Expert Insights and Industry Standards

According to the National Institute of Standards and Technology (NIST), the development and validation of pharmaceutical products require rigorous testing to ensure efficacy and safety. While NIST does not directly regulate veterinary drugs, its guidelines on analytical methods and quality control are widely referenced in the pharmaceutical industry. Amoxicillin Injection adheres to these principles, ensuring that its pharmacokinetic profile and therapeutic effects are well-documented and reproducible.

Conclusion

Amoxicillin Injection is a cornerstone in the treatment of bacterial infections in livestock, offering broad-spectrum activity, favorable pharmacokinetics, and a well-established safety profile. Its application in managing respiratory diseases in cattle and pigs underscores its importance in veterinary medicine. As a product of Shijiazhuang Shimu Pharmaceutical Co., Ltd., it exemplifies the company's dedication to quality and innovation in veterinary healthcare.