Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic, Broad-Spectrum Treatment

Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a critical veterinary antibiotic used for treating bacterial infections in livestock. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and company background, supported by authoritative references and technical specifications.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin derived from ampicillin, designed to combat both Gram-positive and Gram-negative bacterial infections. It is formulated as a sterile solution containing 150mg of amoxicillin per milliliter (150mg/ml), making it suitable for intramuscular administration in cattle and pigs. The product is packaged in 100ml bottles with a 3-year shelf life when stored properly.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy:

• Peak Concentration (Cmax): In cattle, Cmax reaches 3.45 µg/ml 2.45 hours post-administration. In pigs, it achieves 3.54 µg/ml within 2 hours.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with a low plasma protein binding rate (17%). It effectively penetrates pulmonary, pleural, and bronchial tissues, as well as pleural, synovial, and lymphatic fluids.
• Metabolism: The drug undergoes hepatic hydrolysis, converting 20% of the compound into inactive penicilloic acid.
• Excretion: Approximately 60-70% of the drug is excreted unchanged via the kidneys, with secondary elimination through the biliary route and milk.

Applications in Veterinary Medicine

Amoxicillin Injection is indicated for treating bacterial infections caused by susceptible pathogens, including:

• Mannheimia haemolytica and Pasteurella multocida in cattle
• Pasteurella multocida in pigs

Its broad-spectrum activity makes it a preferred choice for respiratory infections in livestock, where rapid bacterial cell wall disruption is critical.

Key Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Administration Route	Intramuscular
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage Conditions	Sealed, protected from light, and out of children's reach
Shelf Life	3 years
Packaging	100ml/bottle

Safety and Adverse Reactions

While generally well-tolerated, Amoxicillin Injection requires careful handling:

• Hypersensitivity: Avoid use in animals with known beta-lactam allergies. Allergic reactions, though rare, can occur.
• Local Reactions: Transient injection site reactions may develop but typically resolve without intervention.
• Milk Withdrawal: Milk from treated animals must not be used for human consumption during treatment and for 96 hours post-treatment.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Based in China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. specializes in veterinary pharmaceuticals, with a focus on antibiotics and antimicrobial agents. The company adheres to international quality standards, ensuring its products meet rigorous safety and efficacy benchmarks for livestock health.

Expert Insights and Regulatory Compliance

According to the National Institute of Standards and Technology (NIST), precise measurement and standardization are critical in pharmaceutical development. Amoxicillin Injection aligns with these principles, as its formulation and dosing are calibrated to ensure consistent therapeutic outcomes. NIST's role in advancing metrology standards underscores the importance of accuracy in veterinary medicine, as highlighted in their research on biomedical measurement technologies.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. represents a reliable solution for managing bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and adherence to safety protocols make it an essential tool in veterinary care. For more details, visit the product page.

References

1. National Institute of Standards and Technology (NIST) - "Advancing Measurement Science for Biomedical Applications."

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. - Product Specifications and Safety Data.