Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic,Broad-Spectrum Treatment

Amoxicillin Injection is a critical pharmaceutical product designed for the treatment of bacterial infections in livestock, particularly in cattle and pigs. As a broad-spectrum antibiotic, it plays a vital role in veterinary medicine by targeting both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, advantages, technical specifications, and applications, while highlighting the company behind this product, Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin, a semisynthetic penicillin, belongs to the amino-penicillin family and is structurally related to ampicillin. It functions as a bactericidal agent, effectively inhibiting the synthesis and repair of bacterial mucopeptide cell walls. This mechanism makes it highly effective against a range of pathogens, including Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory diseases in cattle and pigs.

Key Pharmacokinetic Data:

• Cattle: Peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration.
• Pigs: Peak plasma concentration (Cmax) of 3.54 µg/ml is reached 2 hours post-administration.
• Distribution: Amoxicillin is primarily distributed in the extracellular compartment, with a low plasma protein binding rate (17%). It accumulates in pulmonary, pleural, and bronchial tissues, as well as in pleural, synovial, and lymphatic fluids.
• Metabolism: The drug is metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Amoxicillin is predominantly excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk.

Advantages and Clinical Applications

Amoxicillin Injection offers several advantages that make it a preferred choice in veterinary medicine:

• Broad-Spectrum Activity: It effectively targets both Gram-positive and Gram-negative bacteria, making it suitable for a wide range of infections.
• Fast Onset of Action: The rapid absorption and distribution of the drug ensure quick therapeutic effects, which is critical in treating acute infections.
• Low Protein Binding: The low plasma protein binding (17%) allows for higher free drug concentrations, enhancing its efficacy in tissues.
• Safe for Livestock: While it is contraindicated in animals with known allergies to β-lactams, its safety profile is well-established for use in cattle and pigs.

Indications: Amoxicillin Injection is indicated for the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria. It is particularly effective against respiratory pathogens such as Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.

Important Safety and Usage Guidelines

While Amoxicillin Injection is generally safe, certain precautions must be observed:

• Allergic Reactions: Hypersensitivity (allergy) can occur, and it should not be used in animals with a known history of β-lactam allergies.
• Local Reactions: Transient local reactions at the injection site may occur but are typically mild.
• Withdrawal Periods: The withdrawal period for meat is 28 days, and for milk, it is 4 hours. This ensures that residues do not enter the food supply.
• Storage: The product should be stored in a sealed container111, protected from light, and kept out of reach of children.

Product Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Formulation	Injection (100ml/bottle)
Shelf Life	3 years
Administration Route	Intramuscular
Withdrawal Period (Meat)	28 days
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality products for animal health. With a focus on innovation and compliance with international standards, the company ensures that its products meet the rigorous demands of the veterinary market.

As a leader in the industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. emphasizes research and development to create effective solutions for livestock health. Their commitment to quality is reflected in the production of Amoxicillin Injection, which adheres to strict manufacturing and safety protocols.

Why Choose Amoxicillin Injection?

Amoxicillin Injection stands out due to its efficacy, safety, and ease of use in veterinary settings. Its broad-spectrum activity and favorable pharmacokinetic profile make it an ideal choice for treating bacterial infections in cattle and pigs. Additionally, the product's adherence to withdrawal periods ensures the safety of the food supply chain.

For more information about Amoxicillin Injection, including detailed specifications and usage guidelines, visit the product page on Skyvetpharm.

References

1. National Institute of Standards and Technology (NIST). (n.d.). Driving Innovation. Retrieved from https://www.nist.gov. NIST plays a critical role in advancing technology through precise measurements and research, ensuring the reliability of scientific and industrial standards.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. (n.d.). Amoxicillin Injection. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html. Product specifications and usage guidelines for veterinary applications.