Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic, Broad-Spectrum Treatment

Amoxicillin Injection is a critical pharmaceutical product designed for the treatment of bacterial infections in veterinary medicine. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司), this injection is a broad-spectrum antibiotic that plays a vital role in managing respiratory diseases in livestock such as cattle and pigs. This article delves into the pharmacokinetic properties, applications, safety information, and technical specifications of Amoxicillin Injection, providing a detailed understanding of its efficacy and usage.

Pharmacokinetic Properties

Amoxicillin is a semisynthetic penicillin belonging to the amino-penicillin family. It is structurally similar to ampicillin and functions as a bactericide, effectively targeting both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting the synthesis and repair of the bacterial cell wall, a process critical for microbial survival. However, it is susceptible to beta-lactamases, enzymes produced by certain bacteria that can inactivate penicillin derivatives.

Time-dependent antibiotic: Amoxicillin's effectiveness is closely tied to the duration of exposure to the bacteria. This characteristic necessitates careful dosing to ensure sustained therapeutic levels in the bloodstream.

Key Microbial Targets: The injection is particularly effective against pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory diseases in cattle and pigs. This makes it a preferred choice for veterinarians treating infectious conditions in livestock.

Pharmacokinetic Data

In Cattle: After intramuscular administration, Amoxicillin reaches a maximum plasma concentration (Cmax) of 3.45 µg/ml within 2.45 hours. In Pigs: The Cmax of 3.54 µg/ml is achieved in 2 hours post-injection. These values indicate rapid absorption and distribution, ensuring prompt therapeutic action.

Distribution: Amoxicillin predominantly distributes to the extracellular compartment, facilitated by its low plasma protein binding (17%). It achieves similar concentrations in pulmonary, pleural, and bronchial tissues, as well as in pleural and synovial fluids. This distribution pattern enhances its ability to target infections in respiratory and musculoskeletal systems.

Metabolism: The drug is metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the administered dose). This metabolic pathway reduces its active concentration over time.

Excretion: Amoxicillin is primarily excreted via the kidneys in its active form, with secondary elimination through the biliary route and milk. This excretion profile is crucial for determining withdrawal periods and ensuring safety for both animals and consumers.

Applications and Indications

Indications: Amoxicillin Injection is indicated for the treatment of infections caused by Gram-positive and Gram-negative bacteria. Its broad-spectrum activity makes it suitable for a wide range of bacterial infections, particularly those affecting the respiratory system in livestock.

Veterinary Use: The product is widely used in veterinary medicine to address bacterial infections in cattle and pigs. Its efficacy against Pasteurella multocida and Mannheimia haemolytica highlights its importance in managing respiratory diseases, which are significant economic and health concerns in the agricultural sector.

Safety and Adverse Reactions

Hypersensitivity Reactions: As with all penicillins, Amoxicillin Injection may cause hypersensitivity (allergic) reactions. It should not be administered to animals with a known allergy to beta-lactam antibiotics. Veterinarians must carefully assess the patient's medical history before use.

Local Reactions: Occasional transient local reactions at the injection site may occur. These are typically mild and resolve without intervention.

Milk Withdrawal Period: To ensure the safety of dairy products, milk for human consumption must not be taken during treatment. For cattle, milk can be safely consumed after 96 hours from the last dose. This withdrawal period is critical for maintaining food safety standards.

Storage and Shelf Life

Storage Conditions: The product should be stored in a sealed container111, protected from light, and kept out of reach of children. Proper storage ensures the stability and potency of the medication.

Shelf Life: Amoxicillin Injection has a shelf life of 3 years when stored under recommended conditions. This longevity makes it a practical option for veterinary practices and farms.

Packaging: The injection is available in 100ml bottles, providing a convenient and standardized dosage form for administration.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Formulation	Injectable Solution
Indications	Treatment of bacterial infections in cattle and pigs
Pharmacokinetic Profile	Time-dependent antibiotic with rapid absorption and distribution
Withdrawal Period	28 days for meat; 4 hours for milk
Storage	Sealed, protected from light, out of reach of children
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司) is a reputable manufacturer of veterinary pharmaceuticals, dedicated to developing high-quality products for animal health. With a focus on innovation and compliance, the company ensures its products meet stringent safety and efficacy standards. Their commitment to research and development has positioned them as a trusted partner in the veterinary industry.

For more information about the company and its products, visit their official website: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and safety measures make it a preferred choice for veterinarians. By understanding its technical specifications, applications, and proper usage, stakeholders can ensure optimal outcomes for animal health and food safety.

References

1. National Institute of Standards and Technology (NIST). (n.d.). Driving Innovation. Retrieved from https://www.nist.gov/.

2. Amoxicillin Injection Product Page. (n.d.). Shijiazhuang Shimu Pharmaceutical Co., Ltd.

3. Shijiazhuang Shimu Pharmaceutical Co., Ltd.. (n.d.). Official Website.

4. NIST Standards and Measurements. (n.d.). Retrieved from https://www.nist.gov/.