Amoxicillin Injection-Veterinary Solutions|Broad-Spectrum Antibiotic

Amoxicillin injection is a critical pharmaceutical solution in veterinary medicine, designed to combat bacterial infections in livestock. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and the company behind its production. For detailed specifications and usage guidelines, visit the product page.

Product Overview

Amoxicillin injection is a semisynthetic penicillin antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It is specifically formulated for veterinary use, targeting respiratory infections in cattle and pigs. The product is available in a 100ml bottle with a shelf life of 3 years, ensuring long-term storage and usability (product details).

Key Features

• Composition: 150mg of amoxicillin per ml
• Indication: Treatment of bacterial infections caused by susceptible organisms
• Administration: Intramuscular injection
• Withdrawal Period: 28 days for meat, 4 hours for milk

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin injection is essential for optimizing its therapeutic efficacy. The drug exhibits distinct absorption, distribution, metabolism, and excretion characteristics in different animal species.

Absorption and Distribution

In cattle, the maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration. In pigs, the Cmax of 3.54 µg/ml is reached within 2 hours. Amoxicillin distributes primarily to the extracellular compartment, facilitated by its low plasma protein binding (17%). It effectively reaches tissues such as the lungs, pleura, and bronchial tissues, with concentrations comparable to plasma levels (product specifications).

Metabolism and Excretion

Amoxicillin undergoes hepatic metabolism via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20%). The majority of the drug is excreted unchanged through the kidneys, with secondary excretion via the biliary route and milk. This excretion profile necessitates careful monitoring in lactating animals (pharmacokinetic data).

Applications in Veterinary Medicine

Amoxicillin injection is a cornerstone in treating bacterial infections in livestock, particularly respiratory diseases. Its efficacy against specific pathogens makes it a preferred choice for veterinarians.

Target Pathogens

The antibiotic is effective against:

• Cattle: Mannheimia haemolytica and Pasteurella multocida
• Pigs: Pasteurella multocida

These bacteria are commonly associated with respiratory tract infections, which can lead to significant economic losses in livestock production. The drug's bactericidal action and broad-spectrum activity make it a vital tool in disease management (clinical applications).

Usage Guidelines

Amoxicillin injection should be administered intramuscularly, with the dosage determined by the animal's weight and the severity of the infection. It is crucial to follow the withdrawal period guidelines to ensure food safety: 28 days for meat and 4 hours for milk. The product must be shaken well before use to ensure uniform distribution of the active ingredient (usage instructions).

Safety and Adverse Reactions

While amoxicillin injection is generally safe, it is not without risks. Adverse reactions and precautions must be carefully considered.

Adverse Effects

As with all beta-lactam antibiotics, hypersensitivity reactions (allergies) are possible. Animals with a known allergy to penicillins should not receive this medication. Local reactions at the injection site, such as swelling or redness, may occur but are typically transient (safety information).

Special Warnings

Healthcare professionals must emphasize the importance of adhering to withdrawal periods to prevent residues in milk and meat. Additionally, the product should be stored in a cool, dry place, protected from light, and kept out of reach of children (storage guidelines).

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司) is a leading manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality solutions for animal health. With a focus on innovation and compliance, the company ensures that its products meet rigorous standards for safety and efficacy (company profile).

Commitment to Quality

Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to international pharmaceutical standards, employing advanced manufacturing technologies and stringent quality control measures. Their products are designed to address the diverse needs of the veterinary industry, with a particular emphasis on antibiotics like amoxicillin injection (company mission).

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Formulation	Injectable Solution
Administration Route	Intramuscular
Withdrawal Period (Meat)	28 days
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Conclusion

Amoxicillin injection remains a vital component of veterinary medicine, offering effective treatment for bacterial infections in livestock. Its pharmacokinetic profile, safety considerations, and application in respiratory diseases underscore its importance in animal health. Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to play a pivotal role in supplying reliable pharmaceutical solutions, ensuring the well-being of animals and the sustainability of agricultural practices.

References

NIST (National Institute of Standards and Technology) provides critical standards and measurements that underpin pharmaceutical research and development. While specific references to this product are unavailable, NIST's role in advancing measurement science ensures the accuracy and reliability of pharmaceutical products. For more information, visit NIST's official website.

Authoritative Sources: The information presented is based on the product's technical specifications and clinical guidelines. For further details on pharmaceutical standards, refer to NIST's publications on measurement science and quality assurance (NIST References).