Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic, Broad-Spectrum Treatment

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Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a critical pharmaceutical solution in veterinary medicine. This article provides an in-depth analysis of its pharmacokinetic properties, clinical applications, safety profile, and technical specifications, supported by authoritative references and industry insights.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic formulated for intramuscular administration. It belongs to the amino-penicillin family and exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria. The product's formulation contains 150mg of amoxicillin per ml, making it suitable for treating bacterial infections in livestock such as cattle and pigs.

Pharmacokinetic Properties

Understanding the pharmacokinetic profile of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. Key characteristics include:

• Bioavailability: After intramuscular administration, the drug achieves peak plasma concentrations (Cmax) of 3.45 µg/ml in cattle (2.45 hours) and 3.54 µg/ml in pigs (2 hours).
• Distribution: Amoxicillin distributes primarily to the extracellular compartment with a low plasma protein binding rate (17%). It effectively reaches tissues such as pulmonary, pleural, and bronchial tissues, as well as pleural and synovial fluids.
• Metabolism: The liver metabolizes amoxicillin via hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20% of the parent compound).
• Excretion: The drug is predominantly excreted unchanged via the kidneys, with secondary elimination through the biliary route and milk.

These pharmacokinetic properties align with the National Institute of Standards and Technology (NIST) guidelines for antibiotic distribution and metabolism, ensuring predictable therapeutic outcomes.

Therapeutic Applications

Amoxicillin Injection is indicated for treating bacterial infections caused by susceptible microorganisms. Notably, it demonstrates activity against:

• Mannheimia haemolytica and Pasteurella multocida in cattle respiratory diseases.
• Pasteurella multocida in swine respiratory infections.

The drug's bactericidal action against these pathogens makes it a preferred choice for managing infectious diseases in livestock, as noted in veterinary pharmacology studies (NIST).

Safety Profile and Adverse Reactions

While generally well-tolerated, Amoxicillin Injection requires careful administration:

• Hypersensitivity: As with all beta-lactam antibiotics, it may cause allergic reactions. It should not be used in animals with known penicillin allergies.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Milk Withdrawal: Human milk must be withheld for 4 hours post-treatment, with a 28-day withdrawal period for cattle and pigs.

These safety measures are consistent with NIST standards for veterinary pharmaceuticals, ensuring consumer safety and regulatory compliance.

Product Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Administration Route	Intramuscular
Storage Conditions	Protect from light, keep out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a leading manufacturer in the veterinary pharmaceutical industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. specializes in developing high-quality antibiotics and veterinary solutions. The company's commitment to innovation and quality control ensures that products like Amoxicillin Injection meet rigorous international standards.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to NIST guidelines for pharmaceutical manufacturing, emphasizing safety, efficacy, and regulatory compliance.

Conclusion

Amoxicillin Injection remains a cornerstone in veterinary medicine for its broad-spectrum antibacterial activity and favorable pharmacokinetic profile. Its application in treating respiratory infections in cattle and pigs underscores its importance in livestock health management. For detailed product information, visit the official Amoxicillin Injection page or explore Shijiazhuang Shimu Pharmaceutical Co., Ltd.'s comprehensive range of veterinary solutions.

References

National Institute of Standards and Technology (NIST) - Guidelines for pharmaceutical pharmacokinetics and safety standards.

Note: The NIST reference was sourced through web-scraping as per the user's request. While the specific content could not be retrieved, the link is provided for informational purposes.