Amoxicillin Injection-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic, Broad-Spectrum Treatment

Amoxicillin Injection is a widely used antibiotic in veterinary medicine, designed to treat bacterial infections in livestock such as cattle and pigs. This article provides an in-depth analysis of its pharmacokinetic properties, applications, technical specifications, and the company behind the product, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection belongs to the amino-penicillin family, making it a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, a critical process for microbial survival. The product is specifically formulated for veterinary use, with a concentration of 150mg/ml of amoxicillin in each milliliter of solution.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. Here are the key details:

Peak Concentration (Cmax)

• Cattle: 3.45 µg/ml achieved 2.45 hours post-intramuscular administration.
• Pigs: 3.54 µg/ml reached 2 hours after injection.

Distribution and Metabolism

Amoxicillin distributes primarily in the extracellular compartment, facilitated by its low plasma protein binding (17%). It accumulates in tissues such as the lungs, pleura, and bronchial areas, with concentrations comparable to plasma levels. The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).

Excretion

The majority of Amoxicillin is excreted unchanged through the kidneys, with secondary elimination via the biliary route and milk. This makes it particularly effective in treating infections in lactating animals, though precautions are necessary for milk safety.

Applications in Veterinary Medicine

Amoxicillin Injection is indicated for treating infections caused by susceptible bacteria in cattle and pigs. It is particularly effective against:

• Mannheimia haemolytica and Pasteurella multocida in respiratory diseases of cattle.
• Pasteurella multocida in respiratory infections of pigs.

Its broad-spectrum activity makes it a versatile choice for managing bacterial infections in livestock, reducing the need for multiple medications.

Advantages of Amoxicillin Injection

Several features distinguish Amoxicillin Injection from other antibiotics:

• Time-dependent efficacy: The drug’s bactericidal action is most effective when maintaining consistent plasma concentrations over time.
• Low protein binding: Ensures rapid distribution to target tissues, enhancing therapeutic outcomes.
• Minimal adverse effects: When used as directed, it has a favorable safety profile, with rare instances of hypersensitivity reactions.

Additionally, its shelf life of 3 years and user-friendly packaging (100ml/bottle) make it a practical choice for veterinary practices.

Technical Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Indication	Treatment of bacterial infections in cattle and pigs
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage	Seal, protect from light, and keep out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle

Important Safety Information

While Amoxicillin Injection is generally safe, certain precautions must be observed:

• Allergies: It should not be administered to animals with a known hypersensitivity to beta-lactam antibiotics.
• Local reactions: Transient injection site reactions may occur but are typically mild.
• Milk safety: Milk from treated animals must not be used for human consumption during treatment. A 4-hour withdrawal period is required for milk.

Always follow the manufacturer’s guidelines and consult a veterinarian for proper dosing and administration.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Founded in China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals. The company focuses on developing high-quality antibiotics and other medications to support animal health. Their commitment to research and adherence to international standards ensures the reliability of products like Amoxicillin Injection.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and safety record make it a preferred choice for veterinarians. For more information about the product, visit the Amoxicillin Injection product page.

References

This article incorporates information from the Shijiazhuang Shimu Pharmaceutical Co., Ltd. product documentation. While efforts were made to verify details using authoritative sources like the National Institute of Standards and Technology (NIST), the search encountered technical difficulties. For further scientific validation, consult peer-reviewed veterinary journals or regulatory guidelines.