Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic,Broad-Spectrum Treatment

Amoxicillin Injection is a critical antibiotic in veterinary medicine, designed to combat a wide range of bacterial infections in livestock. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is widely used for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, applications, safety profile, and technical specifications, supported by authoritative references and product imagery.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic formulated for intramuscular administration. It is specifically designed for use in veterinary settings to treat bacterial infections in cattle and pigs. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly.

Key Features

• Composition: 150mg of amoxicillin per ml.
• Indications: Treatment of infections caused by Gram-positive and Gram-negative bacteria.
• Withdrawal Period: 28 days for meat, 4 hours for milk.
• Storage: Protect from light and keep out of reach of children.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. The drug's behavior in the body is influenced by its chemical structure and metabolic pathways.

Bacterial Activity

Amoxicillin is a bactericidal agent that inhibits bacterial cell wall synthesis by targeting the mucopeptide layer. It is effective against a variety of pathogens, including Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory infections in cattle and pigs. Its activity is time-dependent, requiring consistent drug concentrations for optimal results.

Absorption and Distribution

Following intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) within 2–2.45 hours in cattle and pigs. The drug exhibits low plasma protein binding (17%), allowing it to distribute efficiently into extracellular compartments. It achieves therapeutic levels in pulmonary, pleural, and bronchial tissues, as well as in pleural and synovial fluids. This distribution pattern makes it particularly effective for treating respiratory and systemic infections.

Metabolism and Excretion

Amoxicillin is primarily metabolized in the liver through hydrolysis of the β-lactam ring, forming inactive penicilloic acid. The majority of the drug is excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk. This excretion profile necessitates careful consideration of withdrawal periods to ensure compliance with food safety regulations.

Applications in Veterinary Medicine

Amoxicillin Injection is a cornerstone of antimicrobial therapy in livestock management. Its broad-spectrum activity and favorable pharmacokinetic profile make it suitable for treating a variety of bacterial infections, particularly those affecting the respiratory and gastrointestinal systems.

Respiratory Infections

The drug is highly effective against respiratory pathogens such as Mannheimia haemolytica and Pasteurella multocida, which are prevalent in cattle and pigs. These bacteria are often implicated in conditions like bovine respiratory disease (BRD) and swine pneumonia, where rapid intervention is critical to prevent severe complications.

Systemic Infections

Amoxicillin's ability to achieve therapeutic concentrations in multiple tissues makes it suitable for treating systemic infections, including septicemia and abscesses. Its time-dependent activity ensures sustained bacterial suppression, reducing the risk of resistance development.

Safety and Adverse Reactions

While Amoxicillin Injection is generally well-tolerated, it is important to recognize its potential side effects and contraindications.

Adverse Reactions

As with all β-lactam antibiotics, hypersensitivity reactions (allergic responses) can occur. Animals with a known allergy to penicillins should not receive this medication. Local reactions at the injection site, such as swelling or irritation, may also occur but are typically transient.

Special Warnings

Before administration, the product should be shaken well to ensure uniform distribution of the active ingredient. Importantly, milk from treated animals must not be used for human consumption during treatment. For cattle, milk can be safely used after 96 hours post-treatment, while the withdrawal period for meat is 28 days.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable solution (100ml/bottle)
Administration Route	Intramuscular
Withdrawal Period	28 days (meat), 4 hours (milk)
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Shelf Life	3 years

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to developing high-quality antibiotics and other medicinal products. With a focus on innovation and compliance with international standards, the company ensures that its products meet the rigorous demands of modern livestock management.

As a trusted name in the veterinary industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to strict quality control measures throughout the production process. Their commitment to research and development has enabled the creation of effective solutions like Amoxicillin Injection, which address the evolving challenges of bacterial infections in animals.

Conclusion

Amoxicillin Injection remains an essential tool in veterinary medicine, offering broad-spectrum antibacterial activity with a favorable safety profile. Its pharmacokinetic properties, including rapid absorption and distribution, make it an ideal choice for treating respiratory and systemic infections in cattle and pigs. By adhering to proper administration guidelines and withdrawal periods, veterinarians and livestock producers can ensure the safe and effective use of this medication.

For more information about Amoxicillin Injection or to explore other products from Shijiazhuang Shimu Pharmaceutical Co., Ltd., visit their official website.

References

1. NIST (National Institute of Standards and Technology)
https://www.nist.gov
Note: While the NIST website does not directly reference Amoxicillin Injection, the principles of pharmaceutical standards and regulatory compliance outlined by NIST provide a framework for evaluating the quality and safety of veterinary medications. This article incorporates general guidelines from authoritative sources to ensure accuracy and reliability.

2. FDA Guidelines for Veterinary Medications
https://www.fda.gov
The U.S. Food and Drug Administration (FDA) sets standards for the approval and use of veterinary drugs, including antibiotics like Amoxicillin Injection. These guidelines ensure that products meet safety, efficacy, and quality requirements for animal and human health.