Amoxicillin Injection-Veterinary Use|Broad-Spectrum Antibacterial,Pharmacokinetic Profile

Amoxicillin Injection is a critical pharmaceutical product designed to combat bacterial infections in livestock, including cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is a cornerstone in veterinary medicine due to its broad-spectrum efficacy and favorable pharmacokinetic profile. This article provides an in-depth analysis of its functional properties, technical specifications, application scenarios, and company background, ensuring a comprehensive understanding for veterinarians, farmers, and healthcare professionals.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable pharmaceutical manufacturer based in China, specializing in veterinary drugs and animal health solutions. With a commitment to quality and innovation, the company adheres to stringent production standards to ensure the safety and efficacy of its products. Their expertise in developing antibiotics like Amoxicillin Injection reflects their dedication to addressing the evolving challenges in livestock health. For more information about their company profile, visit their official website.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin, a semisynthetic penicillin, is renowned for its broad-spectrum antibacterial activity. It belongs to the amino-penicillin family and functions as a bactericidal agent, targeting both Gram-positive and Gram-negative bacteria. By inhibiting the synthesis and repair of bacterial cell walls, Amoxicillin effectively eliminates pathogens. However, it is susceptible to beta-lactamases, which are enzymes produced by certain bacteria to degrade penicillin-like antibiotics.

Key Pharmacokinetic Data

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic use:

• Cmax (Maximum Plasma Concentration): In cattle, Cmax reaches 3.45 µg/ml at 2.45 hours post-intramuscular administration. In pigs, Cmax is 3.54 µg/ml within 2 hours.
• Distribution: Amoxicillin distributes primarily to the extracellular compartment, with a low plasma protein binding rate (17%). It achieves similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma, and diffuses into pleural, synovial, and lymphatic tissues.
• Metabolism: The drug is metabolized in the liver via hydrolysis of the β-lactam ring, forming inactive penicilloic acid (20% of the original compound).
• Excretion: Amoxicillin is mainly excreted via the kidneys in its active form, with secondary excretion through the biliary route and milk.

Technical Specifications and Product Details

The technical specifications of Amoxicillin Injection are critical for its proper use and storage. Below is a detailed table summarizing the key parameters:

Parameter	Details
Composition	150 mg Amoxicillin per ml
Indications	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours
Storage Conditions	Seal, protect from light, and keep out of reach of children
Packaging	100 ml/bottle
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice to treat bacterial infections in livestock. Its efficacy against specific pathogens makes it a preferred choice for managing respiratory diseases in cattle and pigs. For instance, it is active against Mannheimia haemolytica and Pasteurella multocida, which are common causes of bovine respiratory disease. Similarly, it targets Pasteurella multocida in swine, addressing respiratory infections that can lead to significant economic losses in the agricultural sector.

The drug's broad-spectrum activity allows it to combat a wide range of bacterial infections, making it a versatile tool for veterinarians. Its rapid absorption and distribution in tissues ensure that therapeutic concentrations are achieved quickly, reducing the duration of illness and improving recovery rates.

Advantages of Amoxicillin Injection

Several factors contribute to the popularity of Amoxicillin Injection in veterinary medicine:

• High Efficacy: The drug's ability to inhibit bacterial cell wall synthesis ensures potent antibacterial action.
• Fast Onset of Action: The rapid attainment of Cmax in both cattle and pigs allows for quick therapeutic effects.
• Low Protein Binding: The low plasma protein binding (17%) facilitates effective distribution to target tissues.
• Convenient Administration: The intramuscular route of administration is practical for large animals, minimizing stress and ensuring accurate dosing.

Furthermore, Amoxicillin Injection is cost-effective compared to other antibiotics, making it an accessible solution for farmers and livestock producers. Its established safety profile, when used as directed, ensures minimal risk of adverse effects in treated animals.

Safety and Adverse Reactions

While Amoxicillin Injection is generally safe, it is essential to be aware of potential adverse reactions and precautions:

• Hypersensitivity Reactions: As with all penicillins, it may cause allergic reactions in animals with a known sensitivity to beta-lactams.
• Local Reactions: Transient local reactions at the injection site may occur but are typically mild and self-limiting.
• Milk Withdrawal: Milk from treated animals should not be used for human consumption during treatment. For cattle, milk can be safely used 96 hours after the last dose.

Strict adherence to withdrawal periods is crucial to ensure the safety of food products derived from treated animals. The product label provides detailed instructions on dosage, administration, and safety measures.

Importance of Regulatory Standards

The development and use of antibiotics like Amoxicillin Injection are governed by rigorous regulatory standards to ensure safety, efficacy, and quality. The National Institute of Standards and Technology (NIST), a U.S. federal agency, plays a pivotal role in establishing measurement standards that underpin pharmaceutical research and development. By aligning with such standards, Shijiazhuang Shimu Pharmaceutical Co., Ltd. ensures that its products meet global quality benchmarks.

NIST's work in metrology and standardization supports the accuracy of measurements critical to drug formulation and testing. For example, precise measurements of Amoxicillin concentrations in injectable solutions are essential to guarantee therapeutic effectiveness. As noted by NIST, "Accurate measurements are the foundation of innovation and economic growth" (NIST).

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in the management of bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and ease of administration make it a preferred choice for veterinarians. By adhering to strict regulatory standards and leveraging advancements in pharmaceutical science, the company continues to provide reliable solutions for animal health.

For further details about Amoxicillin Injection, including its product specifications and company information, visit the official website of Shijiazhuang Shimu Pharmaceutical Co., Ltd.

References

1. National Institute of Standards and Technology (NIST). (n.d.). Driving Innovation. Retrieved from https://www.nist.gov/

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. (n.d.). Amoxicillin Injection. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html