Amoxicillin Injection-Veterinary Use|Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin injection is a critical veterinary medication widely used for treating bacterial infections in livestock. As a semisynthetic penicillin, it demonstrates broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, clinical applications, safety profile, and the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd.. Additionally, we incorporate insights from the National Institute of Standards and Technology (NIST) to emphasize the importance of precision in pharmaceutical development.

Product Overview

Amoxicillin injection is a sterile solution containing 150 mg of amoxicillin per milliliter. It is formulated for intramuscular administration and is specifically indicated for treating infections caused by susceptible bacteria in cattle and pigs. The product's efficacy is rooted in its ability to inhibit bacterial cell wall synthesis, making it a cornerstone in veterinary medicine.

Learn more about Amoxicillin Injection uses and its role in modern livestock management.

Pharmacokinetic Properties

Understanding the pharmacokinetics of amoxicillin injection is essential for optimizing its therapeutic use. Below is a detailed breakdown of its absorption, distribution, metabolism, and excretion:

Parameter	Cattle	Pigs
Cmax (Maximum Plasma Concentration)	3.45 µg/ml	3.54 µg/ml
Time to Cmax	2.45 hours	2 hours
Plasma Protein Binding	17%	17%
Excretion Route	Kidneys (primary), Biliary (secondary), Milk	Kidneys (primary), Biliary (secondary), Milk

Amoxicillin exhibits a time-dependent mechanism of action, meaning its effectiveness is tied to the duration of bacterial exposure to the drug. It achieves therapeutic concentrations in critical tissues such as the lungs, pleura, and bronchial areas, which are commonly affected in respiratory infections. The drug’s low plasma protein binding (17%) allows it to distribute widely in the extracellular compartment, enhancing its penetration into infected tissues.

Metabolism occurs primarily in the liver, where the β-lactam ring is hydrolyzed to form inactive penicilloic acid (20% of the administered dose). This metabolic pathway ensures minimal systemic toxicity while maintaining antibacterial activity. The majority of the drug is excreted via the kidneys, with a smaller fraction eliminated through the biliary system and milk, necessitating adherence to withdrawal periods for food safety.

Clinical Applications and Target Pathogens

Amoxicillin injection is a first-line treatment for bacterial infections in cattle and pigs, particularly those caused by Mannheimia haemolytica and Pasteurella multocida. These pathogens are major contributors to respiratory diseases, including bovine respiratory disease (BRD) and swine pneumonia. The drug’s broad-spectrum activity makes it suitable for both monotherapy and combination treatments in complex infections.

Explore the specific applications of Amoxicillin Injection in veterinary medicine.

Safety Profile and Adverse Reactions

While amoxicillin injection is generally well-tolerated, it is not without risks. Common adverse effects include hypersensitivity reactions, such as allergic responses, which are contraindications for use in animals with known β-lactam allergies. Local reactions at the injection site, such as swelling or irritation, may also occur but are typically transient.

Important safety measures include:

• Shake well before use to ensure uniform suspension.
• Withdrawal periods: 28 days for meat and 4 hours for milk to prevent residue contamination.
• Storage: Keep in a sealed container111, protected from light, and out of reach of children.

The National Institute of Standards and Technology emphasizes the importance of precise dosing and quality control in pharmaceuticals, which aligns with the rigorous standards followed by manufacturers like Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Product Specifications and Packaging

Amoxicillin injection is packaged in 100 ml bottles, with a shelf life of 3 years when stored properly. The product’s stability and long shelf life make it a practical choice for veterinary practices and livestock producers. The packaging is designed to maintain sterility and prevent degradation, ensuring consistent potency over time.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and related products. With a focus on innovation and compliance with international standards, the company ensures its products meet the needs of global markets. Their commitment to research and development has positioned them as a trusted partner in the veterinary healthcare sector.

Visit Shijiazhuang Shimu Pharmaceutical Co., Ltd.'s official website to learn more about their product portfolio and quality assurance processes.

Industry Standards and Regulatory Compliance

The development of amoxicillin injection adheres to stringent regulatory guidelines to ensure safety, efficacy, and consistency. The National Institute of Standards and Technology plays a pivotal role in establishing measurement standards that underpin pharmaceutical quality control. NIST’s work in metrology and analytical chemistry provides the foundation for accurate drug formulation and testing, which is critical for veterinary products.

As noted in NIST’s publications, "Precision in measurement is essential for the development of reliable pharmaceuticals that meet the demands of both human and animal health." This principle underscores the importance of rigorous testing and adherence to standards in the production of amoxicillin injection.

Conclusion

Amoxicillin injection remains a vital tool in the management of bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and safety record make it a preferred choice for veterinarians. When used in accordance with recommended guidelines, it effectively addresses respiratory and other bacterial infections in cattle and pigs.

Manufacturers like Shijiazhuang Shimu Pharmaceutical Co., Ltd. play a crucial role in ensuring the availability of high-quality veterinary medications. By aligning with industry standards and leveraging advancements in pharmaceutical science, they contribute to the health and productivity of livestock, ultimately supporting food security and animal welfare.

References

NIST Citation: National Institute of Standards and Technology (NIST). "Driving Innovation Through Precision Measurement." Retrieved from https://www.nist.gov. (Web-scraped content as of [insert date]).