Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd. | Veterinary Antibiotic, Broad-Spectrum Treatment

Amoxicillin Injection is a vital pharmaceutical product designed to address bacterial infections in livestock, particularly in cattle and pigs. As a broad-spectrum antibiotic, it belongs to the amino-penicillin family, offering effective treatment against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of the product's pharmacokinetic properties, technical specifications, applications, safety profile, and the background of its manufacturer, Shijiazhuang Shimu Pharmaceutical Co., Ltd.

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Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin Injection is a time-dependent antibiotic, meaning its efficacy relies on the duration of bacterial exposure to the drug rather than peak concentration. After intramuscular administration, the drug reaches peak plasma concentration (Cmax) within 2 to 2.45 hours in cattle and pigs, respectively. The Cmax values are 3.45 µg/ml in cattle and 3.54 µg/ml in pigs, demonstrating consistent absorption across species.

Once absorbed, amoxicillin distributes primarily into the extracellular compartment, facilitated by its low plasma protein binding (17%). It achieves therapeutic concentrations in critical tissues such as the lungs, pleura, and bronchial tissues, making it effective for respiratory infections. The drug also diffuses into pleural and synovial fluids, as well as lymphatic tissue, enhancing its ability to target pathogens in these areas.

Metabolism occurs in the liver through hydrolysis of the β-lactam ring, converting amoxicillin into inactive penicilloic acid (20%). Excretion is predominantly via the kidneys, with a secondary route through the biliary system and milk. This excretion profile ensures the drug remains active in the body long enough to combat infections effectively.

Key Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages, making it a preferred choice for veterinary applications:

• Broad-Spectrum Activity: Effective against a wide range of bacteria, including Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs.
• Fast Onset of Action: Rapid absorption and distribution ensure quick therapeutic effects, crucial for managing acute infections.
• Low Toxicity: Generally well-tolerated, with minimal side effects when used as directed.
• Convenient Administration: Available in a 100ml bottle, allowing for easy dosing in large animal settings.

Technical Specifications Table

Specification	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Formulation	Injectable Solution
Administration Route	Intramuscular
Peak Concentration (Cmax)	3.45 µg/ml (Cattle), 3.54 µg/ml (Pigs)
Half-Life	Approximately 1.5 hours
Excretion Pathways	Kidneys (primary), Biliary (secondary), Milk
Withdrawal Period	28 days (Cattle and Pigs), 4 hours (Milk)
Storage Conditions	Seal, protect from light, keep out of reach of children
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin Injection is specifically indicated for treating infections caused by susceptible bacteria in livestock. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a critical tool in managing respiratory diseases in cattle and pigs. These pathogens are commonly associated with conditions such as bovine respiratory disease (BRD) and swine pneumonia, which can lead to significant economic losses in the agricultural sector.

Additionally, the drug's ability to achieve therapeutic concentrations in extracellular fluids and tissues ensures its effectiveness in combating systemic infections. Veterinarians often rely on Amoxicillin Injection for its broad-spectrum activity, reducing the need for multiple antibiotics and minimizing the risk of resistance development.

Safety Profile and Adverse Reactions

While Amoxicillin Injection is generally safe, it is essential to adhere to the following precautions:

• Hypersensitivity Risk: As with all penicillins, it may cause allergic reactions. It should not be administered to animals with a known allergy to beta-lactam antibiotics.
• Local Reactions: Transient injection site reactions may occur but are typically mild and resolve without intervention.
• Withdrawal Periods: To ensure food safety, milk from treated cattle must not be used for human consumption for 4 hours post-treatment. The withdrawal period for meat is 28 days.
• Storage: The product must be stored in a sealed container111, protected from light, and kept away from children.

These safety measures are crucial for maintaining the integrity of the food supply chain and ensuring the well-being of both animals and consumers.

About Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality products that meet global standards. With a focus on innovation and research, the company ensures that its products, such as Amoxicillin Injection, are formulated to deliver optimal efficacy and safety.

As a leading player in the veterinary pharmaceutical industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to strict quality control measures, ensuring compliance with international regulations. Their commitment to excellence is reflected in the development of products like Amoxicillin Injection, which are essential for the health and productivity of livestock.

Conclusion

Amoxicillin Injection stands out as a reliable and effective antibiotic for treating bacterial infections in cattle and pigs. Its favorable pharmacokinetic profile, broad-spectrum activity, and safety considerations make it a valuable asset in veterinary medicine. For more information on this product, visit the Amoxicillin Injection page or explore the offerings of Shijiazhuang Shimu Pharmaceutical Co., Ltd..

References

1. National Institute of Standards and Technology (NIST). (n.d.). Retrieved from https://www.nist.gov

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd. (2025). Amoxicillin Injection Product Information. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html

For detailed technical data, safety guidelines, and application protocols, refer to the official product documentation provided by Shijiazhuang Shimu Pharmaceutical Co., Ltd.