Amoxicillin Injection- Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic, Broad-Spectrum

Amoxicillin Injection is a vital veterinary medication designed to combat bacterial infections in livestock. As a broad-spectrum antibiotic, it plays a critical role in maintaining animal health and ensuring the safety of the food supply chain. This article provides an in-depth analysis of the product's amoxicillin injection properties, applications, and the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection is a semisynthetic penicillin antibiotic derived from ampicillin. It is specifically formulated for veterinary use to treat infections caused by both Gram-positive and Gram-negative bacteria. The product is available in a 100ml bottle, with a shelf life of 3 years when stored properly. Its primary application lies in managing respiratory diseases in cattle and pigs, such as those caused by Mannheimia haemolytica and Pasteurella multocida.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for its effective use. After intramuscular administration:

• Cattle: The maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved within 2.45 hours.
• Pigs: The Cmax of 3.54 µg/ml is reached in 2 hours.

The drug is distributed primarily in the extracellular compartment due to its low plasma protein binding (17%). It effectively reaches tissues such as the lungs, pleura, and bronchial areas, with concentrations comparable to plasma levels. Amoxicillin is metabolized in the liver via hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20%). The majority is excreted via the kidneys, with secondary excretion through the biliary route and milk.

Key Features and Advantages

Amoxicillin Injection offers several advantages for veterinary professionals:

• Broad-Spectrum Activity: Effective against a wide range of bacteria, including Mannheimia haemolytica and Pasteurella multocida, which are common pathogens in respiratory infections.
• Time-Dependent Antibiotic: Its efficacy is optimized by maintaining therapeutic concentrations over time, aligning with the drug's mechanism of action.
• Quick Onset of Action: Rapid absorption and distribution ensure prompt treatment of infections.
• Minimal Side Effects: When used as directed, the risk of adverse reactions is low, though hypersensitivity and transient local reactions may occur.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in the treatment of bacterial infections in livestock. Its primary applications include:

• Respiratory Infections: Targeting pathogens like Mannheimia haemolytica in cattle and Pasteurella multocida in pigs.
• Systemic Infections: Managing infections that spread beyond the initial site of entry, such as septicemia or abscesses.
• Post-Surgical Prophylaxis: Preventing bacterial infections following surgical procedures in animals.

The drug's ability to penetrate tissues and fluids makes it particularly effective for treating infections in the respiratory tract, joints, and other organs.

Product Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injection (100ml/bottle)
Indications	Treatment of infections caused by Gram-positive and Gram-negative bacteria.
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours.
Storage	Seal, protect from light, and keep out of reach of children.
Shelf Life	3 years

Usage Guidelines and Safety Precautions

Proper administration of Amoxicillin Injection is critical to ensure efficacy and minimize risks:

• Administration: Shake the bottle well before use. The injection should be administered intramuscularly as directed by a veterinarian.
• Contraindications: Avoid use in animals with known allergies to beta-lactam antibiotics.
• Adverse Reactions: Hypersensitivity reactions, though rare, may occur. Local reactions at the injection site are typically transient.
• Milk Withdrawal: Milk from treated animals should not be used for human consumption during treatment. It can be safely used after 96 hours post-treatment.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer of veterinary pharmaceuticals, dedicated to providing high-quality solutions for animal health. With a focus on research, development, and production, the company ensures that its products meet stringent quality and safety standards. Their commitment to innovation and customer satisfaction has established them as a trusted name in the veterinary industry.

For more information about Shijiazhuang Shimu Pharmaceutical Co., Ltd., visit their official website to explore their product range and services.

Regulatory Compliance and Industry Standards

Amoxicillin Injection adheres to regulatory guidelines to ensure safety and efficacy. The product's formulation and manufacturing processes align with the standards set by national and international veterinary authorities. For additional insights into regulatory compliance in pharmaceuticals, refer to the National Institute of Standards and Technology (NIST), which plays a pivotal role in establishing measurement standards that support the pharmaceutical industry.

Conclusion

Amoxicillin Injection is an essential tool in veterinary medicine, offering a reliable solution for treating bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and adherence to safety standards make it a preferred choice for veterinarians. By understanding its properties and applications, professionals can optimize its use to enhance animal health and ensure the integrity of the food supply chain.

References

NIST (National Institute of Standards and Technology): https://www.nist.gov/

This article incorporates information from Amoxicillin Injection and Shijiazhuang Shimu Pharmaceutical Co., Ltd. to provide a comprehensive overview of the product.