Amoxicillin Injection-Veterinary Use|Broad-Spectrum Antibiotic&Infection Treatment

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Introduction

Amoxicillin Injection is a critical tool in veterinary medicine, designed to combat bacterial infections in livestock such as cattle and pigs. As a semisynthetic penicillin, it belongs to the amino-penicillin family and is renowned for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria. This article delves into the pharmacokinetic properties, applications, safety profile, and company background of Amoxicillin Injection, providing a detailed analysis for veterinary professionals and stakeholders.

Product Overview

Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., Amoxicillin Injection is a sterile solution containing 150mg of amoxicillin per milliliter. It is formulated for intramuscular administration and is widely used in the treatment of respiratory infections caused by pathogens such as Mannheimia haemolytica and Pasteurella multocida in cattle and pigs. The product's efficacy, safety, and compliance with veterinary standards make it a preferred choice in animal healthcare.

Key Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injectable Solution
Administration Route	Intramuscular
Withdrawal Period	28 days for meat, 4 hours for milk
Storage Conditions	Sealed, protected from light, out of reach of children
Shelf Life	3 years

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic use. The drug exhibits distinct absorption, distribution, metabolism, and excretion profiles in different animal species.

Absorption and Distribution

In cattle, the peak plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration. In pigs, the Cmax of 3.54 µg/ml is reached within 2 hours. Amoxicillin's low plasma protein binding (17%) facilitates its distribution into extracellular compartments, including pulmonary, pleural, and bronchial tissues. It also diffuses into pleural, synovial, and lymphatic tissues, ensuring effective targeting of bacterial pathogens in these areas.

Metabolism and Excretion

The liver metabolizes Amoxicillin through hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20% of the administered dose). The majority of the drug is excreted unchanged via the kidneys, with secondary elimination through the biliary route and milk. This excretion profile necessitates caution in lactating animals, as milk must be discarded for 4 hours post-treatment.

Applications in Veterinary Medicine

Amoxicillin Injection is primarily indicated for treating bacterial infections in cattle and pigs. Its broad-spectrum activity makes it effective against a range of pathogens, including those causing respiratory diseases. Key applications include:

• Respiratory Infections: Targeting Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Systemic Infections: Addressing bacterial infections that spread beyond the respiratory tract.
• Preventive Use: Administering in high-risk environments to reduce infection outbreaks.

Safety and Adverse Reactions

While Amoxicillin Injection is generally well-tolerated, certain precautions are necessary:

• Allergic Reactions: Hypersensitivity (allergy) to β-lactams contraindicates its use. Animals with known allergies should not receive the drug.
• Local Reactions: Transient injection site reactions may occur but are typically mild.
• Milk Withdrawal: Milk from treated animals must not be used for human consumption during treatment and for 4 hours post-dose.

Adherence to the 28-day meat withdrawal period ensures compliance with food safety regulations and minimizes residue risks.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medications for livestock. With a focus on innovation and compliance, the company adheres to stringent quality control standards to ensure the safety and efficacy of its products. Their commitment to animal health and agricultural sustainability has established them as a trusted partner in the veterinary industry.

Conclusion

Amoxicillin Injection represents a vital advancement in veterinary medicine, offering a reliable solution for combating bacterial infections in cattle and pigs. Its favorable pharmacokinetic profile, broad-spectrum activity, and safety considerations make it an essential tool for veterinarians. By adhering to proper administration protocols and withdrawal periods, stakeholders can maximize its therapeutic benefits while ensuring food safety and animal welfare.

References

NIST (National Institute of Standards and Technology): https://www.nist.gov
As per NIST's role in developing measurement standards, the accuracy of pharmaceutical formulations like Amoxicillin Injection relies on rigorous testing and validation processes. This ensures compliance with regulatory requirements and maintains the integrity of veterinary medicines (NIST, 2025).

Further Reading

• Amoxicillin Injection Product Page
• Shijiazhuang Shimu Pharmaceutical Co., Ltd. Website