Amoxicillin Injection - Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic, Pharmacokinetics, Safety

Amoxicillin Injection is a critical therapeutic agent in veterinary medicine, renowned for its broad-spectrum antibacterial activity. This article delves into the pharmacokinetic properties, applications, safety profile, and technical specifications of Amoxicillin Injection, while also highlighting the company behind its production, Shijiazhuang Shimu Pharmaceutical Co., Ltd. (石家庄石牧药业有限公司). For detailed information, visit the official product page.

Product Overview and Company Background

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reputable manufacturer specializing in veterinary pharmaceuticals, with a commitment to producing high-quality antibiotics like Amoxicillin Injection. The company’s products are designed to meet stringent veterinary standards, ensuring efficacy and safety for livestock. Learn more about Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Pharmacokinetic Properties

Amoxicillin is a semisynthetic penicillin with a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. It functions as a bactericide by inhibiting bacterial cell wall synthesis, a mechanism that is particularly effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common in respiratory infections in cattle and pigs.

Upon intramuscular administration, Amoxicillin achieves peak plasma concentrations (Cmax) of 3.45 µg/ml in cattle at 2.45 hours and 3.54 µg/ml in pigs at 2 hours. Its low plasma protein binding (17%) facilitates widespread distribution into extracellular compartments, including pulmonary, pleural, and bronchial tissues. This distribution ensures effective concentrations in target areas, making it ideal for treating respiratory infections.

The drug is primarily metabolized in the liver via hydrolysis of the β-lactam ring, resulting in inactive penicilloic acid. Excretion occurs mainly through the kidneys, with a secondary route via the biliary system and milk. This pharmacokinetic profile underscores its suitability for use in livestock, where rapid elimination is critical for minimizing residue risks.

Applications and Target Species

Amoxicillin Injection is indicated for the treatment of infections caused by susceptible bacteria in cattle and pigs. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it a first-line therapy for respiratory diseases, including bovine respiratory disease (BRD) and porcine respiratory disease complex (PRDC). The product is available in a 100ml bottle with a concentration of 150mg/ml, offering flexibility for dosing in various livestock settings.

For detailed usage guidelines, refer to the product specification sheet.

Safety and Adverse Reactions

While generally safe, Amoxicillin Injection carries potential risks. As with all β-lactam antibiotics, hypersensitivity reactions (allergies) may occur, and it should not be administered to animals with a known allergy to penicillins. Local reactions at the injection site, such as swelling or irritation, are occasionally reported but typically transient.

Important Warnings:

• Shake well before use to ensure uniform suspension.
• Milk for human consumption must be withheld during treatment. In cattle, milk can be safely used after a 96-hour withdrawal period following the last dose.

Withdrawal Periods and Storage

Adherence to withdrawal periods is crucial to ensure food safety. For cattle and pigs, the withdrawal period is 28 days, while milk must be discarded for 4 hours post-treatment. Proper storage involves keeping the product sealed, protected from light, and out of reach of children. The shelf life is 3 years when stored under these conditions.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150mg/ml
Administration Route	Intramuscular
Peak Plasma Concentration (Cmax)	Cattle: 3.45 µg/ml (2.45 hours post-dose); Pigs: 3.54 µg/ml (2 hours post-dose)
Half-Life	Varies by species, but generally short due to rapid renal excretion
Withdrawal Period (Meat)	28 days for cattle and pigs
Withdrawal Period (Milk)	4 hours
Storage Conditions	Sealed, protected from light, and out of reach of children
Shelf Life	3 years

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering a balance of efficacy, safety, and practicality. Its pharmacokinetic profile ensures rapid and sustained therapeutic concentrations, while its low risk of adverse effects makes it a preferred choice for treating bacterial infections in cattle and pigs. For further details, explore the product page or contact Shijiazhuang Shimu Pharmaceutical Co., Ltd.

References

1. National Institute of Standards and Technology (NIST). "Accurate Measurements for Pharmaceutical Development." https://www.nist.gov. NIST emphasizes the importance of precise measurements in drug development, ensuring the reliability and consistency of pharmaceutical products.

2. Shijiazhuang Shimu Pharmaceutical Co., Ltd.. "Product Specifications and Safety Guidelines." https://www.skyvetpharm.com. Official documentation provides detailed information on Amoxicillin Injection's formulation and usage.

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