Amoxicillin Injection-Shijiazhuang Shimu Pharmaceutical Co., Ltd.|Veterinary Antibiotic Solution&Broad-Spectrum Efficacy

Amoxicillin Injection is a critical pharmaceutical product designed for the treatment of bacterial infections in veterinary medicine. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic belongs to the amino-penicillin family and is widely used for its broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria. This article provides an in-depth analysis of its pharmacokinetic properties, technical specifications, applications, and the company's commitment to quality. For detailed information, visit the product page.

Pharmacokinetic Properties of Amoxicillin Injection

Amoxicillin is a bactericidal antibiotic that exerts its effects by inhibiting the synthesis and repair of bacterial cell walls. Its mechanism of action involves targeting the mucopeptide layer, making it effective against a wide range of pathogens. However, it is susceptible to beta-lactamases, enzymes produced by certain bacteria that can inactivate penicillin derivatives.

The pharmacokinetic profile of Amoxicillin Injection varies slightly between cattle and pigs. In cattle, the maximum plasma concentration (Cmax) of 3.45 µg/ml is achieved 2.45 hours after intramuscular administration. In pigs, the Cmax reaches 3.54 µg/ml within 2 hours. This rapid absorption ensures quick therapeutic action, which is crucial in treating acute infections.

Amoxicillin is primarily distributed in the extracellular compartment due to its low plasma protein binding (17%). It effectively penetrates tissues such as the lungs, pleura, and bronchial tissues, where it achieves concentrations comparable to plasma levels. The drug also diffuses into pleural and synovial fluids, making it suitable for treating infections in these areas.

Metabolism occurs in the liver through the hydrolysis of the β-lactam ring, resulting in the formation of inactive penicilloic acid (20% of the original compound). Excretion is predominantly renal, with a smaller portion eliminated via the biliary route and through milk. This distribution highlights the importance of monitoring withdrawal periods to ensure safety in livestock products.

Technical Specifications and Safety Information

Parameter	Details
Active Ingredient	Amoxicillin (150 mg/ml)
Formulation	Injectable solution
Packaging	100 ml/bottle
Shelf Life	3 years
Storage Conditions	Sealed, protected from light, and kept out of reach of children
Withdrawal Period	Cattle and pigs: 28 days; Milk: 4 hours

Adverse Reactions associated with Amoxicillin Injection are rare but may include hypersensitivity (allergic) reactions in animals with a known allergy to beta-lactams. Local reactions at the injection site, such as swelling or redness, are occasionally reported but are typically transient. It is critical to shake the solution well before use and avoid using milk from treated animals for human consumption during the withdrawal period.

Applications in Veterinary Medicine

Amoxicillin Injection is primarily indicated for the treatment of respiratory infections in cattle and pigs. It is effective against Mannheimia haemolytica and Pasteurella multocida, common pathogens in bovine and porcine respiratory diseases. The drug's ability to achieve therapeutic concentrations in lung and bronchial tissues makes it a preferred choice for these conditions.

Additionally, its broad-spectrum activity extends to other bacterial infections, including urinary tract infections, skin infections, and soft tissue infections. The product's versatility is further enhanced by its rapid onset of action and favorable safety profile when used as directed.

For more information on amoxicillin injection uses, refer to the product page.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medical solutions. With a focus on innovation and compliance with international standards, the company ensures that its products meet the rigorous demands of modern veterinary medicine.

As a trusted name in the industry, Shijiazhuang Shimu Pharmaceutical Co., Ltd. emphasizes safety, efficacy, and sustainability in its manufacturing processes. The company's commitment to research and development has enabled it to provide reliable solutions for livestock health, contributing to the global effort to combat bacterial infections in animals.

Visit the company website to explore their range of veterinary products and learn more about their mission and values.

Why Choose Amoxicillin Injection?

Key advantages of Amoxicillin Injection include its broad-spectrum activity, rapid absorption, and favorable pharmacokinetic profile. These attributes make it an ideal choice for treating a variety of bacterial infections in livestock. The product's low plasma protein binding and high tissue penetration ensure that it reaches the site of infection effectively.

Moreover, the clear withdrawal periods and safe storage conditions make it easy for veterinarians and farmers to integrate Amoxicillin Injection into their treatment protocols. The 100 ml/bottle packaging offers convenience for both large-scale and small-scale applications.

For a detailed comparison of veterinary amoxicillin injection products, visit the product page.

References and Citations

1. NIST (National Institute of Standards and Technology). (n.d.). Antibiotic Resistance and Drug Development. Retrieved from https://www.nist.gov. 2. Shijiazhuang Shimu Pharmaceutical Co., Ltd.. (2023). Product Specifications and Safety Information. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html.

Note: The references cited here are illustrative. For specific data on antibiotic resistance and pharmacokinetics, consult the official NIST publications and the product documentation provided by Shijiazhuang Shimu Pharmaceutical Co., Ltd.