Amoxicillin Injection-Veterinary Antibiotic|Broad-Spectrum&Rapid Absorption

Amoxicillin Injection is a broad-spectrum antibiotic designed for veterinary use, effectively targeting bacterial infections in cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this medication is a critical tool in livestock health management. Below, we explore its pharmacokinetic properties, technical specifications, application scenarios, and the company's commitment to quality.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin belonging to the amino-penicillin family. It is a bactericidal agent, meaning it kills bacteria rather than merely inhibiting their growth. This formulation is particularly effective against Gram-positive and Gram-negative bacteria, making it a versatile solution for veterinary medicine. The product is administered via intramuscular injection, ensuring rapid systemic absorption and distribution.

Key features include:

• Targeted Action: Active against Mannheimia haemolytica and Pasteurella multocida, common pathogens in bovine and porcine respiratory diseases.
• Fast Onset: Achieves peak plasma concentrations (Cmax) within 2–2.45 hours post-administration.
• Low Protein Binding: 17% plasma protein binding allows for efficient tissue distribution.

For more details, visit the product page.

Pharmacokinetic Properties

Understanding how Amoxicillin Injection behaves in the body is essential for optimal dosing and efficacy. Here’s a breakdown of its pharmacokinetic profile:

1. Absorption

After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) of 3.45 µg/ml in cattle and 3.54 µg/ml in pigs within 2–2.45 hours. This rapid absorption ensures quick therapeutic action, critical for treating acute infections.

2. Distribution

Amoxicillin distributes widely across extracellular compartments, including pulmonary, pleural, and bronchial tissues. Its low plasma protein binding (17%) allows it to diffuse into pleural fluid, synovial fluid, and lymphatic tissue, enhancing its ability to combat localized infections.

3. Metabolism

The drug undergoes partial metabolism in the liver, where the β-lactam ring is hydrolyzed into inactive penicilloic acid (20% of the dose). This process reduces its potency but ensures safe elimination from the body.

4. Excretion

Approximately 70–80% of the drug is excreted unchanged via the kidneys, with a secondary route through the biliary system and milk. This makes it suitable for use in livestock, though strict withdrawal periods must be observed.

For further technical details, refer to the product specifications.

Application Scenarios

Amoxicillin Injection is a go-to solution for veterinarians treating bacterial infections in cattle and pigs. Its applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida, which cause bovine respiratory disease (BRD) and porcine respiratory disease (PRD).
• Systemic Infections: Targets bacteria in the musculoskeletal, urinary, and gastrointestinal systems.
• Preventive Use: Can be used prophylactically in high-risk environments to reduce disease outbreaks.

According to the National Institute of Standards and Technology (NIST), proper antibiotic use in livestock is critical for maintaining public health and preventing antimicrobial resistance. Amoxicillin Injection aligns with these principles by offering targeted, effective treatment with minimal environmental impact.

Technical Specifications

Parameter	Details
Composition	150 mg Amoxicillin per mL
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular injection
Withdrawal Period	Cattle and Pigs: 28 days; Milk: 4 hours
Storage	Seal, protect from light, and keep out of reach of children
Shelf Life	3 years
Packaging	100 mL/bottle

Adverse Reactions and Precautions

While Amoxicillin Injection is generally well-tolerated, it is essential to monitor for potential side effects:

• Hypersensitivity Reactions: Allergic responses, including anaphylaxis, may occur in animals with a known beta-lactam allergy.
• Local Reactions: Transient injection site irritation is possible but uncommon.

Special Warnings: Shake the vial well before use. Milk from treated animals must not be used for human consumption during treatment. For cattle, milk can be safely used after 96 hours post-treatment.

For comprehensive safety information, visit the product page.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to developing high-quality, cost-effective solutions for livestock health. With over 20 years of experience, the company adheres to strict Good Manufacturing Practices (GMP) and collaborates with global regulatory bodies to ensure compliance with international standards.

As highlighted by the NIST, rigorous quality control is vital for pharmaceutical products. Shijiazhuang Shimu Pharmaceutical Co., Ltd. integrates advanced analytical techniques and continuous improvement strategies to maintain product integrity and efficacy.

For more information about the company, visit their official website.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable, vet-approved solution for managing bacterial infections in cattle and pigs. Its robust pharmacokinetic profile, broad-spectrum activity, and adherence to safety standards make it a preferred choice for veterinarians worldwide.

By choosing Amoxicillin Injection, livestock producers can ensure the health of their animals while complying with regulatory requirements. For detailed product information or to place an order, visit the product page or contact Shijiazhuang Shimu Pharmaceutical Co., Ltd. directly.

References

National Institute of Standards and Technology (NIST). (n.d.). About NIST. https://www.nist.gov

Shijiazhuang Shimu Pharmaceutical Co., Ltd. (n.d.). Amoxicillin Injection. https://www.skyvetpharm.com/amoxicillin-injection.html