Amoxicillin Injection-Veterinary Antibiotic|Broad-Spectrum Bacterial Infection Treatment

Amoxicillin Injection is a broad-spectrum antibiotic designed for veterinary use, offering effective treatment for bacterial infections in cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this amoxicillin injection is a trusted solution for managing respiratory diseases caused by Gram-positive and Gram-negative bacteria. This article explores its pharmacokinetic properties, technical specifications, application scenarios, and the company background behind this critical veterinary medication.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin belonging to the amino-penicillin family. It is a bactericidal agent that targets the cell wall synthesis of bacteria, making it highly effective against Mannheimia haemolytica and Pasteurella multocida—common pathogens in respiratory infections among cattle and pigs. The 150mg/ml formulation ensures precise dosing, while its 28-day withdrawal period and 4-hour milk withdrawal align with veterinary drug regulations to ensure animal and consumer safety.

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Key Features and Advantages

Amoxicillin Injection stands out due to its time-dependent antibacterial activity and rapid absorption. Here are its core features:

• Broad-Spectrum Activity: Effective against both Gram-positive and Gram-negative bacteria, including Mannheimia haemolytica and Pasteurella multocida.
• Fast Onset of Action: Achieves peak plasma concentrations (Cmax) within 2–2.45 hours post-injection in cattle and pigs.
• Good Tissue Penetration: Distributes efficiently into pulmonary, pleural, and bronchial tissues, ensuring targeted treatment of respiratory infections.
• Low Protein Binding: With only 17% plasma protein binding, it maintains high free drug levels for sustained efficacy.
• Safe Excretion: Primarily excreted via the kidneys, minimizing systemic toxicity.

Technical Specifications

The following table summarizes the technical parameters of Amoxicillin Injection:

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Pharmacokinetics	Cmax in cattle: 3.45 µg/ml (2.45h); Cmax in pigs: 3.54 µg/ml (2h)
Distribution	Extracellular compartment; accumulates in pulmonary, pleural, and synovial fluids
Metabolism	Hydrolyzed in the liver to inactive penicilloic acid (20%)
Excretion	80% via kidneys; 20% via biliary and milk routes
Storage	Sealed, protected from light; shelf life: 3 years
Packaging	100ml/bottle
Withdrawal Period	Cattle/Pigs: 28 days; Milk: 4 hours

Application Scenarios

Amoxicillin Injection is widely used in veterinary medicine for treating respiratory infections in livestock. Its applications include:

• Cattle: Treating Mannheimia haemolytica-induced pneumonia and other respiratory diseases.
• Pigs: Managing Pasteurella multocida infections, a common cause of swine respiratory syndrome.
• General Use: Addressing bacterial infections in immunocompromised animals or post-surgical cases.

The time-dependent mechanism of Amoxicillin ensures prolonged bacterial suppression, reducing the risk of antimicrobial resistance. Its short milk withdrawal period makes it ideal for dairy cattle without compromising milk safety.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Founded in China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals. The company adheres to international quality standards and focuses on innovative drug formulations for livestock health. Their Amoxicillin Injection is a testament to their commitment to safe, effective, and affordable veterinary solutions.

For more information about their products and services, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Important Safety Information

As with all beta-lactam antibiotics, Amoxicillin Injection may cause hypersensitivity reactions. It should not be used in animals with a known allergy to penicillins. Local reactions at the injection site are rare but transient. Always shake the vial well before use and follow withdrawal period guidelines to ensure food safety.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a versatile and reliable solution for veterinary bacterial infections. Its broad-spectrum activity, optimal pharmacokinetics, and compliance with regulatory standards make it a preferred choice for cattle and pig health management. For veterinary professionals and livestock producers, this product represents a critical tool in combating respiratory diseases while ensuring animal welfare and food safety.

References

While specific NIST standards for amoxicillin injection were not found during this search, the pharmacokinetic data and withdrawal period guidelines align with general veterinary drug regulations outlined by FDA and WHO. For authoritative information on antimicrobial standards, consult NIST or FDA resources.