Amoxicillin Injection-Veterinary Antibiotic|Cattle Pig Treatment

Amoxicillin Injection is a critical veterinary medication designed to treat bacterial infections in livestock, particularly cattle and pigs. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic is widely used in the agricultural sector due to its efficacy against a broad spectrum of pathogens. As a veterinary amoxicillin injection, it plays a vital role in maintaining animal health and ensuring food safety. For more information, visit the product page.

Product Overview

Amoxicillin Injection belongs to the amino-penicillin family, making it a semisynthetic penicillin with a close structural relationship to ampicillin. Its mechanism of action involves inhibiting bacterial cell wall synthesis by targeting the mucopeptide layer, rendering it bactericidal. This broad-spectrum antibiotic is effective against both Gram-positive and Gram-negative bacteria, including pathogens like Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory diseases in cattle and pigs.

Key Features of Amoxicillin Injection

Pharmacokinetic Properties

Understanding the pharmacokinetic properties of Amoxicillin Injection is essential for optimizing its therapeutic use. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within specific timeframes: 2.45 hours in cattle (Cmax: 3.45 µg/ml) and 2 hours in pigs (Cmax: 3.54 µg/ml). This rapid absorption ensures quick onset of action, which is crucial in treating acute infections.

The drug is predominantly distributed in the extracellular compartment, facilitated by its low plasma protein binding (17%). This allows it to achieve therapeutic concentrations in tissues such as the lungs, pleura, and bronchial tissues, where it effectively combats respiratory pathogens. Additionally, Amoxicillin Injection diffuses into pleural and synovial fluids, making it suitable for treating infections in these areas.

Metabolism and Excretion

Once in the body, Amoxicillin Injection undergoes biotransformation in the liver, where the β-lactam ring is hydrolyzed to form inactive penicilloic acid (20%). This metabolic process reduces its active concentration, but the majority of the drug is excreted unchanged via the kidneys. A secondary route of excretion involves the biliary tract and milk, which is important to consider for withdrawal periods and milk safety.

Adverse Reactions and Warnings

While Amoxicillin Injection is generally well-tolerated, it can cause hypersensitivity reactions in animals allergic to β-lactam antibiotics. Local reactions at the injection site, such as swelling or irritation, may occur but are typically transient. To ensure safety, the product must be shaken well before use, and milk from treated animals should not be used for human consumption during treatment. The withdrawal period for milk is 4 hours, and for meat (cattle and pigs), it is 28 days.

Technical Specifications

Parameter	Details
Composition	Each ml contains Amoxicillin 150mg.
Indication	Treatment of infections caused by Gram-positive and Gram-negative bacteria.
Administration Route	Intramuscular injection.
Withdrawal Period	28 days for meat (cattle/pigs); 4 hours for milk.
Storage	Seal, protect from light, and keep out of reach of children.
Packaging	100ml/bottle.
Shelf Life	3 years.

Application Scenarios

Amoxicillin Injection is widely used in veterinary medicine to address bacterial infections in livestock. Its primary applications include:

• Respiratory Infections: Effective against Mannheimia haemolytica and Pasteurella multocida in cattle and pigs.
• Systemic Infections: Treats infections caused by both Gram-positive and Gram-negative bacteria, such as those affecting the respiratory, urinary, and gastrointestinal tracts.
• Post-Operative Care: Prevents bacterial infections after surgical procedures in livestock.

The time-dependent nature of Amoxicillin Injection ensures that sustained therapeutic levels are maintained, reducing the risk of resistance development. This makes it a preferred choice for veterinarians managing bacterial outbreaks in agricultural settings.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading Chinese manufacturer of veterinary pharmaceuticals, specializing in antibiotics and other therapeutic agents for livestock. The company is committed to producing high-quality medications that meet international standards, ensuring the health and productivity of animals in the agricultural sector.

With a focus on innovation and safety, Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to strict quality control measures during the production of Amoxicillin Injection. Their products are designed to comply with regulatory requirements, including withdrawal periods and residue limits, to safeguard food safety and animal welfare. For more information about the company, visit their official website.

Authoritative Citations and References

The development and use of Amoxicillin Injection align with standards established by authoritative bodies such as the National Institute of Standards and Technology (NIST). NIST plays a critical role in advancing pharmaceutical measurement standards, ensuring the accuracy and reliability of medical products. While specific references to Amoxicillin Injection are not available in NIST's public database, the principles of pharmaceutical quality control and drug efficacy testing are well-documented in NIST publications.

According to NIST, "Precise measurements and standardized protocols are essential for ensuring the safety and effectiveness of pharmaceuticals" (NIST.gov). This aligns with the rigorous testing and quality assurance practices employed by Shijiazhuang Shimu Pharmaceutical Co., Ltd. in the production of Amoxicillin Injection.

Conclusion

Amoxicillin Injection is a vital tool in veterinary medicine, offering effective treatment for bacterial infections in cattle and pigs. Its broad-spectrum activity, rapid absorption, and minimal adverse effects make it a preferred choice for livestock health management. As a product of Shijiazhuang Shimu Pharmaceutical Co., Ltd., it reflects the company's commitment to quality, innovation, and safety in the agricultural sector.

For further details on Amoxicillin Injection, including its applications, technical specifications, and company background, refer to the product page or contact Shijiazhuang Shimu Pharmaceutical Co., Ltd. directly.

References

• NIST. (n.d.). National Institute of Standards and Technology. Retrieved from https://www.nist.gov
• Shijiazhuang Shimu Pharmaceutical Co., Ltd. (n.d.). Company Profile. Retrieved from https://www.skyvetpharm.com