Amoxicillin Injection-Veterinary Use|Bacterial Infection Treatment

Introduction

Amoxicillin Injection is a cornerstone in veterinary medicine, offering a potent solution for bacterial infections in livestock. As a broad-spectrum antibiotic, it targets both Gram-positive and Gram-negative bacteria, making it indispensable for treating respiratory diseases in cattle and pigs. This article delves into the pharmacological properties, applications, safety protocols, and the company behind this essential medication, Shijiazhuang Shimu Pharmaceutical Co., Ltd.. For a deeper understanding of its scientific foundation, explore the National Institute of Standards and Technology (NIST)’s role in advancing pharmaceutical standards.

Product Overview

Amoxicillin Injection is a semisynthetic penicillin designed for intramuscular administration. Its active ingredient, amoxicillin, is a bactericidal agent that disrupts bacterial cell wall synthesis. This product is formulated to meet the rigorous demands of veterinary care, ensuring efficacy and safety in treating infections in livestock. Key features include:

• Composition: Each milliliter contains 150mg of amoxicillin.
• Indication: Effective against infections caused by Gram-positive and Gram-negative bacteria.
• Packaging: Available in 100ml bottles, with a shelf life of 3 years when stored properly.

Pharmacokinetic Properties

The pharmacokinetics of Amoxicillin Injection highlight its rapid absorption and distribution, ensuring therapeutic concentrations at infection sites. Key data include:

• Cmax (Maximum Concentration):
  • Cattle: 3.45 µg/ml at 2.45 hours post-administration.
  • Pigs: 3.54 µg/ml at 2 hours post-administration.
• Distribution: Amoxicillin predominantly resides in the extracellular compartment, with low plasma protein binding (17%). It achieves similar concentrations in pulmonary, pleural, and bronchial tissues as in plasma, facilitating effective treatment of respiratory infections.
• Metabolism: The liver hydrolyzes the β-lactam ring, producing inactive penicilloic acid (20% of the original compound).
• Excretion: Primarily via the kidneys, with secondary routes including the biliary system and milk.

These properties underscore the drug’s suitability for rapid bacterial clearance, as noted in NIST’s research on pharmaceutical efficacy standards.

Applications in Veterinary Medicine

Amoxicillin Injection is a vital tool for treating bacterial infections in livestock, particularly respiratory diseases. Its targets include:

• Cattle: Mannheimia haemolytica and Pasteurella multocida.
• Pigs: Pasteurella multocida.

The drug’s time-dependent mechanism ensures sustained bacterial suppression, making it ideal for managing acute and chronic infections. For more on its application, refer to Amoxicillin Injection’s detailed specifications.

Safety and Precautions

While effective, Amoxicillin Injection requires careful administration to mitigate risks:

• Adverse Reactions: Hypersensitivity (allergy) is possible, particularly in animals with a history of β-lactam allergies. Local reactions at the injection site may occur transiently.
• Withdrawal Periods:
  • Cattle and Pigs: 28 days.
  • Milk: 4 hours.
• Storage: Keep sealed, protected from light, and out of reach of children.

Always follow Shijiazhuang Shimu Pharmaceutical Co., Ltd.’s guidelines to ensure safe use.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

As a leading manufacturer in veterinary pharmaceuticals, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is committed to developing high-quality antibiotics like Amoxicillin Injection. Their dedication to innovation and compliance with international standards ensures that their products meet the highest safety and efficacy benchmarks. Learn more about their mission and products on their official website.

Product Specifications Table

Conclusion

Amoxicillin Injection stands as a testament to the advancements in veterinary pharmacology, offering a reliable solution for bacterial infections in livestock. Its robust pharmacokinetic profile, coupled with the expertise of Shijiazhuang Shimu Pharmaceutical Co., Ltd., ensures that it remains a trusted choice for veterinarians and farmers alike. For further insights into pharmaceutical standards, explore the work of NIST, which plays a pivotal role in shaping global measurement and testing protocols.

References

National Institute of Standards and Technology (NIST). (n.d.). Driving Innovation. Retrieved from https://www.nist.gov.