Amoxicillin Injection-Veterinary Use|Bacterial Infections Treatment

Amoxicillin Injection is a vital pharmaceutical solution in veterinary medicine, designed to combat bacterial infections in livestock. This article provides an in-depth analysis of its pharmacokinetic properties, clinical applications, and technical specifications, while highlighting the expertise of its manufacturer, Shijiazhuang Shimu Pharmaceutical Co., Ltd..

Product Overview

Amoxicillin Injection is a broad-spectrum antibiotic belonging to the amino-penicillin family, closely related to ampicillin. It is a bactericidal agent effective against both Gram-positive and Gram-negative bacteria. The drug works by inhibiting bacterial cell wall synthesis, a critical process for microbial survival. Amoxicillin Injection is specifically formulated for veterinary use, targeting respiratory infections in cattle and pigs caused by pathogens like Mannheimia haemolytica and Pasteurella multocida.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. Here’s a detailed breakdown:

Absorption and Distribution

Following intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) within 2–2.45 hours. In cattle, Cmax is 3.45 µg/ml, while in pigs, it reaches 3.54 µg/ml. The drug exhibits low plasma protein binding (17%), facilitating its distribution into extracellular compartments. It achieves therapeutic concentrations in pulmonary, pleural, and bronchial tissues, as well as in pleural, synovial, and lymphatic fluids.

Metabolism and Excretion

Amoxicillin undergoes hepatic metabolism via hydrolysis of the β-lactam ring, producing inactive penicilloic acid (20% of the administered dose). The majority of the drug is excreted unchanged through the kidneys, with secondary excretion via the biliary route and milk.

Adverse Reactions and Safety Considerations

As with all β-lactam antibiotics, Amoxicillin Injection carries a risk of hypersensitivity reactions. It should not be used in animals with known allergies to penicillins. Localized, transient injection site reactions may occur. Amoxicillin Injection also requires careful management of withdrawal periods to ensure food safety:

• Cattle and Pigs: 28 days
• Milk: 4 hours

Storage instructions emphasize sealing the product and protecting it from light. The shelf life is 3 years, with a 100ml/bottle packaging format.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Indication	Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Storage	Sealed, protected from light, out of reach of children
Shelf Life	3 years

Applications in Veterinary Medicine

Amoxicillin Injection is a cornerstone in treating respiratory infections in livestock. Its efficacy against Mannheimia haemolytica and Pasteurella multocida makes it indispensable for managing bovine and porcine respiratory diseases. The drug’s rapid absorption and tissue penetration ensure targeted action, minimizing systemic side effects.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Based in China, Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a trusted manufacturer of veterinary pharmaceuticals. The company adheres to stringent quality control standards, ensuring the safety and efficacy of its products. Their commitment to innovation and compliance with international regulations positions them as a reliable partner in animal health care.

Authority and Expertise: NIST’s Role in Pharmaceutical Standards

The National Institute of Standards and Technology (NIST) plays a critical role in establishing measurement standards that underpin pharmaceutical quality. According to NIST, "Accurate measurements are essential for ensuring the consistency and safety of medical products" (NIST). These standards align with the rigorous testing protocols used by manufacturers like Shijiazhuang Shimu Pharmaceutical Co., Ltd. to validate the potency and purity of Amoxicillin Injection.

Conclusion

Amoxicillin Injection exemplifies the intersection of scientific innovation and veterinary care. Its robust pharmacokinetic profile, coupled with the expertise of its manufacturer, ensures effective treatment for livestock infections. For more information, visit Amoxicillin Injection or explore Shijiazhuang Shimu Pharmaceutical Co., Ltd.’s commitment to animal health.

References

NIST. (2025). Measurement Standards for Pharmaceutical Safety. Retrieved from https://www.nist.gov