Amoxicillin Injection-Veterinary Use|Broad-Spectrum Antibiotic&Infection Treatment

Introduction to Amoxicillin Injection

Amoxicillin Injection is a critical pharmaceutical solution designed for veterinary use, offering effective treatment for bacterial infections in livestock. As a broad-spectrum antibiotic, it belongs to the amino-penicillin family, closely related to ampicillin. This medication is particularly valuable in addressing respiratory diseases in cattle and pigs, which are common and economically significant in the agricultural sector. The Amoxicillin Injection is formulated to ensure rapid and effective therapeutic outcomes while adhering to strict safety and efficacy standards.

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic use. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within specific timeframes: 2.45 hours in cattle and 2 hours in pigs. This rapid absorption ensures quick onset of action, which is critical in treating acute infections. The drug's low plasma protein binding (17%) facilitates its distribution to extracellular compartments, including pulmonary, pleural, and bronchial tissues, where it exerts its antibacterial effects.

Amoxicillin is primarily metabolized in the liver through hydrolysis of the β-lactam ring, resulting in the formation of inactive penicilloic acid. However, the majority of the drug is excreted unchanged via the kidneys, with a secondary route through the biliary system and milk. This excretion pattern necessitates careful consideration of withdrawal periods to ensure the safety of food products derived from treated animals.

Indications and Applications

The Amoxicillin Injection is indicated for the treatment of infections caused by both Gram-positive and Gram-negative bacteria. Its efficacy against specific pathogens, such as Mannheimia haemolytica and Pasteurella multocida, makes it a preferred choice for respiratory diseases in cattle and pigs. These bacteria are notorious for causing significant morbidity and mortality in livestock, leading to substantial economic losses for farmers.

By targeting the bacterial cell wall synthesis, Amoxicillin acts as a bactericidal agent, effectively eliminating the causative organisms. This mechanism of action is particularly advantageous in severe infections where rapid microbial clearance is essential. The drug's ability to diffuse into pleural and synovial fluids further enhances its effectiveness in treating infections involving these tissues.

Advantages of Amoxicillin Injection

Several factors contribute to the widespread use of Amoxicillin Injection in veterinary medicine. Its broad-spectrum activity allows for the treatment of a wide range of bacterial infections, reducing the need for multiple medications. The drug's favorable pharmacokinetic profile ensures that therapeutic concentrations are achieved quickly, minimizing the risk of treatment failure.

Another significant advantage is its relatively low incidence of adverse reactions. While hypersensitivity (allergic) reactions can occur, they are rare and typically transient. Local reactions at the injection site may occasionally be observed, but these are generally mild and resolve without intervention. The drug's safety profile is further enhanced by its short half-life and efficient excretion, which reduces the risk of systemic toxicity.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin
Concentration	150 mg/ml
Indications	Gram-positive and Gram-negative bacterial infections
Withdrawal Period (Cattle/Pigs)	28 days
Withdrawal Period (Milk)	4 hours
Storage Conditions	Seal, protect from light, keep out of reach of children
Shelf Life	3 years
Packaging	100 ml/bottle

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd., a reputable manufacturer of veterinary pharmaceuticals, is committed to producing high-quality medications that meet international standards. The company's dedication to innovation and quality assurance ensures that products like the Amoxicillin Injection are safe, effective, and reliable for veterinary use. With a focus on research and development, Shijiazhuang Shimu Pharmaceutical Co., Ltd. continues to play a vital role in advancing animal health and welfare.

Important Warnings and Precautions

As with all penicillins, Amoxicillin Injection should not be administered to animals with a known allergy to β-lactam antibiotics. Hypersensitivity reactions, although rare, can occur and may require immediate veterinary intervention. It is crucial to follow the prescribed dosage and administration guidelines to minimize the risk of adverse effects.

Additionally, the withdrawal period for milk must be strictly observed. Milk from treated animals should not be used for human consumption during the withdrawal period, ensuring the safety of dairy products. The 4-hour withdrawal period for milk allows sufficient time for the drug to be metabolized and excreted, reducing the risk of residual antibiotic presence in milk.

Conclusion

The Amoxicillin Injection is an essential tool in the treatment of bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and safety record make it a preferred choice for veterinarians and farmers. By adhering to proper usage guidelines and withdrawal periods, the drug ensures effective treatment while safeguarding the health of both animals and consumers.

As emphasized by the National Institute of Standards and Technology (NIST), precision in pharmaceutical standards is critical for ensuring the safety and efficacy of veterinary medications. Shijiazhuang Shimu Pharmaceutical Co., Ltd. aligns with these principles, contributing to the advancement of veterinary medicine and the protection of public health.

References

National Institute of Standards and Technology (NIST). (n.d.). Retrieved from https://www.nist.gov/