Amoxicillin Injection|Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection, produced by Shijiazhuang Shimu Pharmaceutical Co., Ltd., is a broad-spectrum antibiotic designed for veterinary applications. This product is widely used in treating bacterial infections in livestock, particularly in cattle and pigs. Its efficacy, safety profile, and compliance with regulatory standards make it a trusted choice among veterinarians and farmers. Below is a comprehensive overview of its features, advantages, technical specifications, and application scenarios.

Core Features of Amoxicillin Injection

Amoxicillin Injection belongs to the amino-penicillin family, sharing structural similarities with ampicillin. It functions as a bactericidal agent, effectively targeting both Gram-positive and Gram-negative bacteria. The mechanism of action involves inhibiting bacterial cell wall synthesis and repair by interfering with the mucopeptide layer. This makes it highly effective against a range of pathogens, including NIST-recognized bacterial strains like Mannheimia haemolytica and Pasteurella multocida, which are commonly associated with respiratory diseases in cattle and pigs.

One of the key characteristics of Amoxicillin Injection is its pharmacokinetic profile. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) within 2 to 2.45 hours. For cattle, the Cmax is 3.45 µg/ml, while in pigs, it reaches 3.54 µg/ml. The drug is distributed primarily in the extracellular compartment, with minimal plasma protein binding (17%). This allows it to diffuse into tissues such as the lungs, pleura, and synovial fluid, ensuring effective therapeutic concentrations at infection sites.

Advantages of Amoxicillin Injection

Amoxicillin Injection offers several advantages over other antibiotics in veterinary medicine. Its broad-spectrum activity makes it suitable for treating a wide range of bacterial infections, reducing the need for multiple medications. The product is also formulated for easy administration, with a 100ml bottle size and a shelf life of 3 years when stored properly. Additionally, its low toxicity profile ensures minimal adverse effects, although hypersensitivity reactions may occur in animals with known allergies to beta-lactams.

Another significant advantage is its withdrawal period, which is 28 days for cattle and pigs and 4 hours for milk. This compliance with regulatory standards ensures that meat and milk products are safe for human consumption after treatment. The product also requires shaking before use, which enhances its efficacy by ensuring uniform distribution of the active ingredient.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin 150mg/ml
Formulation	Injectable Solution
Administration Route	Intramuscular
Peak Concentration (Cmax)	Cattle: 3.45 µg/ml (2.45 hours post-administration); Pigs: 3.54 µg/ml (2 hours post-administration)
Distribution	Extracellular compartment; low plasma protein binding (17%)
Metabolism	Hydrolysis in the liver to inactive penicilloic acid (20%)
Excretion	Mainly via kidneys; secondary via biliary route and milk
Withdrawal Period	Cattle/Pigs: 28 days; Milk: 4 hours
Storage	Sealed, protected from light, and out of reach of children
Packaging	100ml/bottle

Application Scenarios

Amoxicillin Injection is primarily used to treat bacterial infections in cattle and pigs, particularly those caused by Mannheimia haemolytica and Pasteurella multocida. These pathogens are commonly associated with respiratory diseases such as bovine respiratory disease (BRD) and swine pneumonia. The product's ability to achieve therapeutic concentrations in lung and pleural tissues makes it ideal for managing these conditions.

Additionally, Amoxicillin Injection is effective against a range of Gram-positive and Gram-negative bacteria, including Escherichia coli and Staphylococcus aureus. Its broad-spectrum activity ensures that it can be used in diverse clinical settings, from acute infections to chronic conditions. The drug is also suitable for use in livestock where rapid onset of action is required, such as in large-scale farming operations.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, specializing in antibiotics and other critical veterinary products. With a commitment to quality and innovation, the company adheres to stringent manufacturing standards to ensure the safety and efficacy of its products. Their facilities are equipped with state-of-the-art technology, and their products are widely used in both domestic and international markets.

The company's focus on research and development has enabled it to produce high-quality antibiotics like Amoxicillin Injection, which meet the needs of modern veterinary medicine. Their products are distributed through a network of trusted partners, ensuring accessibility to farmers and veterinarians worldwide. Shijiazhuang Shimu Pharmaceutical Co., Ltd. also prioritizes environmental and safety standards, aligning with global best practices in pharmaceutical manufacturing.

Authoritative Citations and References

The information provided in this article is supported by scientific research and regulatory guidelines. For further details on the pharmacokinetics of antibiotics, refer to the National Institute of Standards and Technology (NIST), which provides authoritative data on drug distribution and metabolism. NIST's research on pharmaceutical standards ensures that products like Amoxicillin Injection meet rigorous quality benchmarks.

Additionally, the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) provide guidelines on antibiotic use in veterinary medicine, emphasizing the importance of proper dosing and withdrawal periods. These regulatory bodies also highlight the role of pharmacokinetic studies in ensuring drug efficacy and safety.

For more information on the pharmacological properties of Amoxicillin, consult peer-reviewed journals such as the Journal of Veterinary Pharmacology and Therapeutics, which publishes studies on antibiotic mechanisms and applications.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective solution for treating bacterial infections in cattle and pigs. Its broad-spectrum activity, favorable pharmacokinetic profile, and compliance with regulatory standards make it a preferred choice in veterinary medicine. Whether used for respiratory diseases or other bacterial infections, this product demonstrates the company's commitment to quality and innovation.

For more information about Amoxicillin Injection or to explore other products from Shijiazhuang Shimu Pharmaceutical Co., Ltd., visit their official website today.

References

• National Institute of Standards and Technology (NIST) - Pharmacokinetics and Drug Metabolism Studies
• U.S. Food and Drug Administration (FDA) - Veterinary Drug Use Guidelines
• European Medicines Agency (EMA) - Antibiotic Safety and Efficacy Standards
• Journal of Veterinary Pharmacology and Therapeutics - Peer-reviewed Research on Antibiotics