Amoxicillin Injection-Veterinary Use|Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection, a critical tool in veterinary medicine, is a broad-spectrum antibiotic derived from the amino-penicillin family. Developed by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this product plays a vital role in treating bacterial infections in livestock such as cattle and pigs. This article delves into its pharmacokinetic properties, applications, safety profile, and the company's commitment to quality, supported by authoritative references from the National Institute of Standards and Technology (NIST).

Product Overview

Amoxicillin Injection is a semisynthetic penicillin with a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. It is particularly effective against pathogens like Mannheimia haemolytica and Pasteurella multocida, which are common causes of respiratory diseases in cattle and pigs. The product is formulated to ensure rapid absorption and distribution, making it a preferred choice for veterinarians in treating acute infections.

Key Features

• Active Ingredient: Amoxicillin (150mg/ml)
• Indication: Treatment of bacterial infections caused by Gram-positive and Gram-negative bacteria
• Administration Route: Intramuscular injection
• Packaging: 100ml/bottle
• Shelf Life: 3 years

Pharmacokinetic Properties

Understanding the pharmacokinetics of Amoxicillin Injection is essential for optimizing its therapeutic efficacy. The drug exhibits time-dependent antibacterial activity, meaning its effectiveness is influenced by the duration of exposure to the pathogen rather than peak concentration.

Absorption and Distribution

After intramuscular administration, Amoxicillin reaches peak plasma concentrations (Cmax) within 2 to 2.45 hours in cattle and pigs. The drug is primarily distributed in the extracellular compartment, facilitated by its low plasma protein binding (17%). This allows it to achieve therapeutic levels in critical tissues such as the lungs, pleura, and bronchial tissues, where it effectively targets respiratory pathogens.

Metabolism and Excretion

Amoxicillin is metabolized in the liver through hydrolysis of the β-lactam ring, forming the inactive metabolite penicilloic acid (20%). The majority of the drug is excreted unchanged via the kidneys, with a secondary route through the biliary system and milk. This excretion profile underscores the importance of adhering to withdrawal periods to ensure food safety.

Applications in Veterinary Medicine

Amoxicillin Injection is widely used in veterinary practice for managing bacterial infections in livestock. Its broad-spectrum activity makes it suitable for treating a variety of conditions, including respiratory, skin, and urinary tract infections. The drug's ability to penetrate tissues and fluids ensures effective eradication of pathogens in these areas.

Target Pathogens

• Cattle: Mannheimia haemolytica, Pasteurella multocida
• Pigs: Pasteurella multocida

According to the National Institute of Standards and Technology (NIST), the accurate measurement and standardization of antibiotics like Amoxicillin are critical for ensuring their efficacy and safety. NIST's research on pharmaceutical standards provides a framework for validating the quality of veterinary drugs, including their pharmacokinetic profiles and therapeutic outcomes.

Safety and Precautions

While Amoxicillin Injection is generally well-tolerated, it is not without risks. As with all β-lactam antibiotics, hypersensitivity reactions can occur, particularly in animals with a known allergy to penicillins. Local reactions at the injection site, such as swelling or irritation, are also possible but typically transient.

Withdrawal Periods

• Cattle and Pigs: 28 days
• Milk: 4 hours

The withdrawal period is a crucial consideration for farmers and veterinarians to ensure that residues do not persist in food products. Adhering to these guidelines is essential for maintaining consumer safety and compliance with regulatory standards.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd., based in China, is a reputable manufacturer of veterinary pharmaceuticals. The company's commitment to quality and innovation is evident in its production of Amoxicillin Injection, which meets stringent international standards. Their focus on research and development ensures that their products address the evolving needs of the veterinary industry.

Product Specifications Table

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Formulation	Injection
Administration Route	Intramuscular
Pharmacokinetic Profile	Time-dependent, with Cmax achieved within 2-2.45 hours
Metabolism	Liver hydrolysis to penicilloic acid
Excretion	Primarily via kidneys, with secondary routes through biliary and milk
Withdrawal Period	28 days (cattle/pigs), 4 hours (milk)
Packaging	100ml/bottle
Shelf Life	3 years

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a reliable and effective antibiotic for treating bacterial infections in livestock. Its favorable pharmacokinetic profile, broad-spectrum activity, and adherence to safety guidelines make it a cornerstone of veterinary medicine. As highlighted by NIST's research on pharmaceutical standards, the importance of precise measurements and quality control in antibiotic production cannot be overstated. For more information on Amoxicillin Injection, visit the product page.

References

National Institute of Standards and Technology (NIST). (n.d.). Pharmaceutical Standards and Measurement. Retrieved from https://www.nist.gov/

Shijiazhuang Shimu Pharmaceutical Co., Ltd.. (n.d.). Amoxicillin Injection. Retrieved from https://www.skyvetpharm.com/amoxicillin-injection.html