Amoxicillin Injection | Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Amoxicillin Injection is a critical veterinary medication designed to combat bacterial infections in livestock, particularly in cattle and pigs. Manufactured by Shijiazhuang Shimu Pharmaceutical Co., Ltd., this antibiotic belongs to the amino-penicillin family and is widely used for its broad-spectrum efficacy. This article explores the pharmacokinetic properties, technical specifications, application scenarios, and the company's commitment to quality in veterinary medicine.

Understanding Amoxicillin Injection

Amoxicillin is a semisynthetic penicillin antibiotic that targets both Gram-positive and Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, making it a potent antibiotic for veterinary use. Its mechanism of action involves binding to penicillin-binding proteins (PBPs) in the bacterial cell membrane, which disrupts the cross-linking of peptidoglycan, leading to cell lysis.

The pharmacokinetic properties of Amoxicillin Injection are crucial for its effectiveness. After intramuscular administration, the drug reaches peak plasma concentrations (Cmax) in cattle within 2.45 hours and in pigs within 2 hours. This rapid absorption ensures timely therapeutic action. The drug's low plasma protein binding (17%) allows it to distribute effectively into extracellular compartments, including pulmonary, pleural, and bronchial tissues, which are common sites of infection in livestock.

Key Features and Advantages

Amoxicillin Injection offers several advantages, making it a preferred choice for veterinarians:

• Broad-spectrum activity: Effective against a wide range of bacteria, including Mannheimia haemolytica and Pasteurella multocida, which are prevalent in respiratory diseases in cattle and pigs.
• Time-dependent efficacy: The drug's concentration in the bloodstream must be maintained above the minimum inhibitory concentration (MIC) for a sufficient duration to ensure bacterial eradication.
• Minimal adverse reactions: While hypersensitivity is a risk, local reactions at the injection site are typically transient and manageable.
• Short withdrawal periods: The withdrawal period for meat is 28 days, and for milk, it is 4 hours, ensuring compliance with food safety regulations.

Technical Specifications

Parameter	Details
Active Ingredient	Amoxicillin (150mg/ml)
Indications	Treatment of infections caused by Gram-positive and Gram-negative bacteria
Administration Route	Intramuscular
Peak Plasma Concentration (Cmax)	Cattle: 3.45 µg/ml at 2.45 hours; Pigs: 3.54 µg/ml at 2 hours
Metabolism	Hydrolysis in the liver to inactive penicilloic acid (20%)
Excretion	Mainly via kidneys; secondary via biliary route and milk
Storage	Seal, protect from light, keep out of reach of children
Shelf Life	3 years
Packaging	100ml/bottle

Application Scenarios

Amoxicillin Injection is particularly effective in treating respiratory infections in cattle and pigs. For instance, it is used to combat Mannheimia haemolytica in cattle, a common cause of bovine respiratory disease (BRD), and Pasteurella multocida in pigs, which leads to conditions like swine pneumonia. The drug's ability to achieve therapeutic concentrations in lung and pleural tissues makes it ideal for these applications.

Additionally, its use in veterinary amoxicillin injection extends to skin and soft tissue infections, urinary tract infections, and post-surgical prophylaxis. The rapid onset of action and favorable safety profile contribute to its widespread adoption in livestock management.

Company Background: Shijiazhuang Shimu Pharmaceutical Co., Ltd.

Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a leading manufacturer of veterinary pharmaceuticals, dedicated to producing high-quality antibiotics and medications. With a focus on innovation and compliance with international standards, the company ensures that its products meet the rigorous demands of modern veterinary medicine.

The company's commitment to veterinary amoxicillin injection is reflected in its adherence to strict quality control measures. Each batch of Amoxicillin Injection undergoes comprehensive testing to guarantee potency, purity, and safety. This dedication to excellence has earned the company a reputation for reliability in the global veterinary pharmaceutical market.

Important Safety Information

Before administering amoxicillin injection, it is crucial to ensure that the animal is not allergic to beta-lactam antibiotics. Hypersensitivity reactions, though rare, can be severe and require immediate veterinary attention. Additionally, the product should be shaken well before use to ensure uniform distribution of the active ingredient.

Special warnings include the prohibition of using milk from treated animals for human consumption during the withdrawal period. For cattle, milk can be safely used after 96 hours from the last treatment, while the meat withdrawal period is 28 days. These guidelines are essential to prevent antibiotic residues in food products, ensuring consumer safety.

Compliance and Regulatory Standards

Shijiazhuang Shimu Pharmaceutical Co., Ltd. adheres to stringent regulatory standards to ensure the safety and efficacy of its products. The company's manufacturing processes align with Good Manufacturing Practices (GMP) and are regularly audited by regulatory authorities. This commitment to compliance is further reinforced by the inclusion of detailed product information, such as amoxicillin injection 1g specifications, on their official website.

For further information on amoxicillin injection uses and amoxicillin injection for veterinary use, visit Shijiazhuang Shimu Pharmaceutical Co., Ltd.'s product page.

Conclusion

Amoxicillin Injection by Shijiazhuang Shimu Pharmaceutical Co., Ltd. is a vital tool in the treatment of bacterial infections in livestock. Its broad-spectrum activity, favorable pharmacokinetic profile, and adherence to safety standards make it a trusted choice for veterinarians worldwide. By understanding its technical specifications and application scenarios, livestock managers can optimize its use to improve animal health and productivity.

References

NIST (National Institute of Standards and Technology) provides critical standards and guidelines for pharmaceutical testing and measurement. For information on antibiotic residue testing and regulatory compliance in veterinary medicine, refer to the following resource:

https://www.nist.gov

For further details on pharmaceutical standards, visit NIST's Standards and Measurements page.