Amoxicillin and Colistin Sulfate Powder

Amoxicillin is a broad-spectrum antibiotic of the amino-penicillin family with close structural relationship to ampicillin.

Amoxicillin is a bactericide and is active against Gram-positive and Gram-negative bacteria. It inhibits the synthesis and reparation of the bacterial mucopeptide cell wall.

Amoxicillin is a semisynthetic penicillin and susceptible to the action of bacterial beta-lactamases.

Amoxicillin is a time-dependent antibiotic.

Amoxicillin is active against the following microorganisms which are involved in respiratory diseases in cattle: Mannheimia haemolytica and Pasteurella multocida. Amoxicillin is also active against Pasteurella multocida that is involved in respiratory diseases in pig.

Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

In cattle Cmax (3.45 µg/ml) is reached 2.45 hours after intramuscular administration. In pigs Cmax (3.54 µg/ml) is reached 2 hours after intramuscular administration.

Amoxicillin is mainly distributed to the extra-cellular compartment. Its distribution into tissues is facilitated by its low degree of plasma protein binding (17%). Concentrations in pulmonary, pleural and bronchial tissues are similar to plasma concentrations. Amoxicillin diffuses into pleural and synovial fluid and into lymphatic tissue.

Amoxicillin is biotransformed in the liver by hydrolysis of the ß-lactam ring leading to inactive penicilloic acid (20%).

Amoxicillin is mainly excreted in active form via the kidneys, and secondarily by the biliary route and through milk.

Colistin: As 80% of the dose can be recovered unchanged in the urine, and there is no biliary excretion, it can be assumed that the remaining drug is inactivated in the tissues, however the mechanism is unknown.

Dosage And Administration：By oral administration.
Chicken: 0.5g per 1 litre drink water for 5 days.Pigs: 1g per 1kg feed.

Adverse Reaction：No adverse reaction to follow the recommended dosage.Special Warnings：Do not use in animals with known hypersensitivity to the active ingredients. Use cautiously with tetracyclines, chloramphenicol, macrolides, and lincomycins. Replace drinking water once every 12 hours to ensure efficacy. Not used in laying period for laying hens.

Withdrawal PeriodChicken: 8 days.

Storage：Seal and store in a dry place.Keep out of reach of children.
Packaging：100g/bagShelf Life：3 years.