Ampicillin And Cloxacillin Intramammary Infusion

COMPOSITION:

It is mainly used to treat breast infections caused by Gram-positive bacteria and Gram-negative bacteria.

 

 


Product Detail

Product Tags

 

Product Description

Each syringe contains:

Ampicillin

75mg

Cloxacillin

200mg

 

Indicaiton:

It is mainly used to treat breast infections caused by Gram-positive bacteria and Gram-negative bacteria.

 

Pharmacodynamic Properties

Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.

 

Pharmacokinetic Properties

Ampicillin is well-absorbed from the GI tract (though food reduces its absorption), and reaches peak concentrations in one to two hours. The bioavailability is around 62% for parenteral routes. Unlike other penicillins, which usually bind 60–90% to plasma proteins, ampicillin binds to only 15–20%.


Mean urinary excretion of cloxacillin after an oral dose of 500 mg was found to be 37%. Total urinary excretion in healthy volunteers was 62% of an intravenously injected dose of 750 mg (250 mg/hr for three hours). The plasma half-life of cloxacillin is reported to be 25 minutes in healthy volunteers following infusion of 750 mg over a 3 hour period. The plasma half-life in uremic patients was increased to 49 minutes. Cloxacillin passage across the CNS barrier is insufficient for practical purposes unless the meninges are inflamed. Cloxacillin passes the placental barrier as do the penicillins to the extent of about 50% of the mothers plasma level.

 

Dosage And Administration:For Breast Tube Injection
Lactating Cow: After-milking, 5.0g is injected into each milk chamber, and administered once every 12 hours according to the condition of the disease.
Special Warnings:Designed for use in lactating mastitis.


Withdrawal Period

Cow: 28 days.
Milk: 60 hours.
48 hours of abandoned milk.


Storage:Seal and store in a cool and dark place.
Do not store above 30℃.
Packaging:5g/syringe
Shelf Life:3 years.

 

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